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  A Subset of Skin Macrophages Contributes to the Seruveillance and Regeneration of Local Nerves

Kolter, J., Feuerstein, R., Zeis, P., Hagemeyer, N., Paterson, N., d’Errico, P., et al. (2019). A Subset of Skin Macrophages Contributes to the Seruveillance and Regeneration of Local Nerves. Immunity, 50, 1482-1497. doi:org/10.1016/j.immuni.2019.05.009.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-E6C8-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-E6C9-6
Genre: Journal Article

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 Creators:
Kolter, Julia1, Author
Feuerstein, Reinhild1, Author
Zeis, Patrice2, Author
Hagemeyer, Nora1, Author
Paterson, Neil2, Author
d’Errico, Paolo1, Author
Baasch, Sebastian1, Author
Amann, Lukas2, Author
Masuda, Takahiro1, Author
Lösslein, Anne1, Author
Gharun, Kourosh1, Author
Meyer-Luehmann, Melanie1, Author
Waskow, Claudia1, Author
Franzke, Claus-Werner1, Author
Grün, Dominic2, Author              
Lämmermann, Tim2, Author              
Prinz, Marco1, Author
Henneke, Philipp1, Author
Affiliations:
1External Organizations, ou_persistent22              
2Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, 79108 Freiburg, DE, ou_2243640              

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 Abstract: The skin comprises tissue macrophages as the most abundant resident immune cell type. Their diverse tasks including resistance against invading pathogens, attraction of bypassing immune cells from vessels, and tissue repair require dynamic specification. Here, we delineated the postnatal development of dermal macrophages and their differentiation into subsets by adapting single-cell transcriptomics, fate mapping, and imaging. Thereby we identified a phenotypically and transcriptionally distinct subset of prenatally seeded dermal macrophages that self-maintained with very low postnatal exchange by hematopoietic stem cells. These macrophages specifically interacted with sensory nerves and surveilled and trimmed the myelin sheath. Overall, resident dermal macrophages contributed to axon sprouting after mechanical injury. In summary, our data show long-lasting functional specification of macrophages in the dermis that is driven by stepwise adaptation to guiding structures and ensures codevelopment of ontogenetically distinct cells within the same compartment.

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Language(s): eng - English
 Dates: 2019-06-182019
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: org/10.1016/j.immuni.2019.05.009
 Degree: -

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Title: Immunity
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 50 Sequence Number: - Start / End Page: 1482 - 1497 Identifier: ISSN: 1074-7613
CoNE: https://pure.mpg.de/cone/journals/resource/954925604783