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  Unified prebiotically plausible synthesis of pyrimidine and purine RNA ribonucleotides

Becker, S., Feldmann, J., Wiedemann, S., Okamura, H., Schneider, C., Iwan, K., et al. (2019). Unified prebiotically plausible synthesis of pyrimidine and purine RNA ribonucleotides. Science, 366(6461), 76-82. doi:10.1126/science.aax2747.

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 Creators:
Becker, Sidney1, 2, Author
Feldmann, Jonas1, Author
Wiedemann, Stefan1, Author
Okamura, Hidenori1, 3, Author
Schneider, Christina1, Author
Iwan, Katharina1, 4, Author
Crisp, Antony1, Author
Rossa, Martin1, Author
Amatov, Tynchtyk1, 5, Author              
Carell, Thomas1, Author
Affiliations:
1Center for Integrated Protein Science, Department of Chemistry, LMU München, Butenandtstrasse 5-13, 81377 München, Germany, ou_persistent22              
2Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK, ou_persistent22              
3Institute for Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577, Japan, ou_persistent22              
4Centre for Translational Omics, University College London, Great Ormond Street Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK, ou_persistent22              
5Research Department List, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445585              

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 Abstract: Theories about the origin of life require chemical pathways that allow formation of life’s key building blocks under prebiotically plausible conditions. Complex molecules like RNA must have originated from small molecules whose reactivity was guided by physico-chemical processes. RNA is constructed from purine and pyrimidine nucleosides, both of which are required for accurate information transfer, and thus Darwinian evolution. Separate pathways to purines and pyrimidines have been reported, but their concurrent syntheses remain a challenge. We report the synthesis of the pyrimidine nucleosides from small molecules and ribose, driven solely by wet-dry cycles. In the presence of phosphate-containing minerals, 5′-mono- and diphosphates also form selectively in one-pot reactions. The pathway is compatible with purine synthesis, allowing the concurrent formation of all Watson-Crick bases.

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Language(s): eng - English
 Dates: 2019-03-082019-08-212019-10-04
 Publication Status: Published in print
 Pages: 7
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1126/science.aax2747
 Degree: -

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Title: Science
  Other : Science
Source Genre: Journal
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Publ. Info: Washington, D.C. : American Association for the Advancement of Science
Pages: - Volume / Issue: 366 (6461) Sequence Number: - Start / End Page: 76 - 82 Identifier: ISSN: 0036-8075
CoNE: https://pure.mpg.de/cone/journals/resource/991042748276600_1