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  Single-cell profiling identifies myeloid cell subsets with distinct fates during neuro inflammation

Jordão, M. J. C., Sankowski, R., Brendecke, S. M., Sagar, S., Locatelli, G., Tai, Y.-H., et al. (2019). Single-cell profiling identifies myeloid cell subsets with distinct fates during neuro inflammation. Science, 363. doi:10.1126/science.aat7554.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-E8F6-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-E8F7-0
Genre: Journal Article

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 Creators:
Jordão, Marta Joana Costa1, Author
Sankowski, Roman1, Author
Brendecke, Stefanie M.1, Author
Sagar, Sagar2, Author
Locatelli, Giuseppe1, Author
Tai, Yi-Heng1, Author
Tay, Tuan Leng1, Author
Schramm, Eva1, Author
Armbruster, Stephan1, Author
Hagemeyer, Nora1, Author
Groß, Olaf1, Author
Mai, Dominic1, Author
Çiçek, Özgün1, Author
Falk, Thorsten1, Author
Kerschensteiner, Martin1, Author
Grün, Dominic2, Author              
Prinz, Marco1, Author
Affiliations:
1External Organizations, ou_persistent22              
2Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, 79108 Freiburg, DE, ou_2243640              

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 Abstract: The innate immune cell compartment is highly diverse in the healthy central nervous system (CNS), including parenchymal and non-parenchymal macrophages. However, this complexity is increased in inflammatory settings by the recruitment of circulating myeloid cells. It is unclear which disease-specific myeloid subsets exist and what their transcriptional profiles and dynamics during CNS pathology are. Combining deep single-cell transcriptome analysis, fate mapping, in vivo imaging, clonal analysis, and transgenic mouse lines, we comprehensively characterized unappreciated myeloid subsets in several CNS compartments during neuroinflammation. During inflammation, CNS macrophage subsets undergo self-renewal, and random proliferation shifts toward clonal expansion. Last, functional studies demonstrated that endogenous CNS tissue macrophages are redundant for antigen presentation. Our results highlight myeloid cell diversity and provide insights into the brain's innate immune system.

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Language(s): eng - English
 Dates: 2019-01-25
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1126/science.aat7554
 Degree: -

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Title: Science
  Other : Science
Source Genre: Journal
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Publ. Info: Washington, D.C. : American Association for the Advancement of Science
Pages: - Volume / Issue: 363 Sequence Number: - Start / End Page: - Identifier: ISSN: 0036-8075
CoNE: https://pure.mpg.de/cone/journals/resource/991042748276600_1