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  Dissociable spatial memory systems revealed by typical and atypical development

Julian, J. B., Kamps, F. S., Epstein, R. A., & Dilks, D. D. (2019). Dissociable spatial memory systems revealed by typical and atypical development. Developmental Science, 22(2): e12737. doi:10.1111/desc.12737.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0004-F038-E Version Permalink: https://hdl.handle.net/21.11116/0000-000C-DB6E-3
Genre: Journal Article

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Locator:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391167/ (Preprint)
Description:
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OA-Status:
Green

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 Creators:
Julian, J. B.1, 2, Author
Kamps, F. S.1, Author
Epstein, R. A.1, Author
Dilks, D. D.1, Author
Affiliations:
1External Organizations, ou_persistent22              
2Department Psychology (Doeller), MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_2591710              

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Free keywords: boundary; hippocampus; landmark; navigation; Williams–Beuren syndrome
 Abstract: Rodent lesion studies have revealed the existence of two causally dissociable spatial memory systems, localized to the hippocampus and striatum that are preferentially sensitive to environmental boundaries and landmark objects, respectively. Here we test whether these two memory systems are causally dissociable in humans by examining boundary- and landmark-based memory in typical and atypical development. Adults with Williams syndrome (WS)—a developmental disorder with known hippocampal abnormalities—and typical children and adults, performed a navigation task that involved learning locations relative to a boundary or a landmark object. We found that boundary-based memory was severely impaired in WS compared to typically-developing mental-age matched (MA) children and chronological-age matched (CA) adults, whereas landmark-based memory was similar in all groups. Furthermore, landmark-based memory matured earlier in typical development than boundary-based memory, consistent with the idea that the WS cognitive phenotype arises from developmental arrest of late maturing cognitive systems. Together, these findings provide causal and developmental evidence for dissociable spatial memory systems in humans.

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Language(s): eng - English
 Dates: 2018-09-032019-03
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1111/desc.12737
PMID: 30176106
 Degree: -

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Project name : -
Grant ID : -
Funding program : -
Funding organization : Emory Child Study Center
Project name : -
Grant ID : -
Funding program : -
Funding organization : Williams Syndrome Association
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Grant ID : 0966142, SBE- 1041707
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Funding organization : National Science Foundation (NSF)
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Grant ID : -
Funding program : -
Funding organization : National Institutes of Health (NIH)
Project name : -
Grant ID : R01EY022350, T32EY007092
Funding program : -
Funding organization : National Eye Institute (NEI)
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Grant ID : T32HD071845
Funding program : -
Funding organization : National Institute of Child Health and Human Development (NICHD)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Emory College of Arts and Sciences, Emory University

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Title: Developmental Science
  Other : Dev. Sci.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Oxford, UK : Blackwell
Pages: - Volume / Issue: 22 (2) Sequence Number: e12737 Start / End Page: - Identifier: ISSN: 1363-755X
CoNE: https://pure.mpg.de/cone/journals/resource/963018343339