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  The functional repertoire contained within the native microbiota of the model nematode Caenorhabditis elegans

Zimmermann, J., Obeng, N., Yang, W., Pees, B., Petersen, C., Waschina, S., et al. (2020). The functional repertoire contained within the native microbiota of the model nematode Caenorhabditis elegans. The ISME Journal, 14, 26-38. doi:10.1038/s41396-019-0504-y.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-EDFA-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-8D46-E
Genre: Journal Article

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 Creators:
Zimmermann, Johannes, Author
Obeng, Nancy, Author
Yang, Wentao, Author
Pees, Barbara, Author
Petersen, Carola, Author
Waschina, Silvio, Author
Kissoyan, Kohar A., Author
Aidley, Jack, Author
Hoeppner, Marc P., Author
Bunk, Boyke, Author
Spröer, Cathrin, Author
Leippe, Matthias, Author
Dierking, Katja, Author
Kaleta, Christoph, Author
Schulenburg, Hinrich1, Author              
Affiliations:
1Max Planck Fellow Group Antibiotic Resistance Evolution, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_2600692              

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 Abstract: The microbiota is generally assumed to have a substantial influence on the biology of multicellular organisms. The exact functional contributions of the microbes are often unclear and cannot be inferred easily from 16S rRNA genotyping, which is commonly used for taxonomic characterization of bacterial associates. In order to bridge this knowledge gap, we here analyzed the metabolic competences of the native microbiota of the model nematode Caenorhabditis elegans. We integrated whole-genome sequences of 77 bacterial microbiota members with metabolic modeling and experimental characterization of bacterial physiology. We found that, as a community, the microbiota can synthesize all essential nutrients for C. elegans. Both metabolic models and experimental analyses revealed that nutrient context can influence how bacteria interact within the microbiota. We identified key bacterial traits that are likely to influence the microbe’s ability to colonize C. elegans (i.e., the ability of bacteria for pyruvate fermentation to acetoin) and affect nematode fitness (i.e., bacterial competence for hydroxyproline degradation). Considering that the microbiota is usually neglected in C. elegans research, the resource presented here will help our understanding of this nematode’s biology in a more natural context. Our integrative approach moreover provides a novel, general framework to characterize microbiota-mediated functions.

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Language(s): eng - English
 Dates: 2019-06-112019-02-152019-07-172019-09-042020-01
 Publication Status: Published in print
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 Identifiers: DOI: 10.1038/s41396-019-0504-y
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Title: The ISME Journal
  Other : The ISME journal : multidisciplinary journal of microbial ecology
Source Genre: Journal
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Publ. Info: Basingstoke : Nature Publishing Group
Pages: - Volume / Issue: 14 Sequence Number: - Start / End Page: 26 - 38 Identifier: ISSN: 1751-7370
CoNE: https://pure.mpg.de/cone/journals/resource/1751-7370