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  Gene-diet interactions associated with complex trait variation in an advanced intercross outbred mouse line

Vorobyev, A., Gupta, Y., Sezin, T., Koga, H., Bartsch, Y. C., Belheouane, M., et al. (2019). Gene-diet interactions associated with complex trait variation in an advanced intercross outbred mouse line. Nature Communications, 10: 4097. doi:10.1038/s41467-019-11952-w.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-EE1F-F Version Permalink: http://hdl.handle.net/21.11116/0000-0004-EE20-C
Genre: Journal Article

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 Creators:
Vorobyev, Artem, Author
Gupta, Yask, Author
Sezin, Tanya, Author
Koga, Hiroshi, Author
Bartsch, Yannic C., Author
Belheouane, Meriem1, Author              
Künzel, Sven2, Author              
Sina, Christian, Author
Schilf, Paul, Author
Körber-Ahrens, Heiko, Author
Beltsiou, Foteini, Author
Lara Ernst, Anna, Author
Khil’chenko, Stanislav, Author
Al-Aasam, Hassanin, Author
Manz, Rudolf A., Author
Diehl, Sandra, Author
Steinhaus, Moritz, Author
Jascholt, Joanna, Author
Kouki, Phillip, Author
Boehncke, Wolf-Henning, Author
Mayadas, Tanya N., AuthorZillikens, Detlef, AuthorSadik, Christian D., AuthorNishi, Hiroshi, AuthorEhlers, Marc, Author              Möller, Steffen, AuthorBieber, Katja, AuthorBaines, John F.1, Author              Ibrahim, Saleh M., AuthorLudwig, Ralf J., Author more..
Affiliations:
1Guest Group Evolutionary Genomics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445638              
2Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445635              

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 Abstract: Phenotypic variation of quantitative traits is orchestrated by a complex interplay between the environment (e.g. diet) and genetics. However, the impact of gene-environment interactions on phenotypic traits mostly remains elusive. To address this, we feed 1154 mice of an autoimmunity-prone intercross line (AIL) three different diets. We find that diet substantially contributes to the variability of complex traits and unmasks additional genetic susceptibility quantitative trait loci (QTL). By performing whole-genome sequencing of the AIL founder strains, we resolve these QTLs to few or single candidate genes. To address whether diet can also modulate genetic predisposition towards a given trait, we set NZM2410/J mice on similar dietary regimens as AIL mice. Our data suggest that diet modifies genetic susceptibility to lupus and shifts intestinal bacterial and fungal community composition, which precedes clinical disease manifestation. Collectively, our study underlines the importance of including environmental factors in genetic association studies.

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Language(s): eng - English
 Dates: 2019-02-212019-08-132019-09-102019
 Publication Status: Published in print
 Pages: -
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 Rev. Method: -
 Identifiers: DOI: 10.1038/s41467-019-11952-w
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Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 10 Sequence Number: 4097 Start / End Page: - Identifier: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723