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Free keywords:
pyrylium salts; primary amino groups; deaminative transformations; radical chemistry; nickel catalysis; photoredox catalysis
Abstract:
Primary amino groups represent an ubiquitous category of functionalities in synthetic building blocks, drugs, and natural products.Therefore, such functionalities offer themselves as perfect handles for late-stage functionalization, and the development of robust and efficient strategies to transform these groups is highly desirable. Despite the extremely challenging activation of the C–N bond, the past few years have witnessed the rapid development of deaminative transformations using pyrylium salts as activating reagents. In most cases, the pyridinium salts formed were activated by single electron transfer, giving alkyl radicals which were used in a series of transformations via nickel and photoredox catalysis. This short review aims to give an overview to related properties of pyrylium salts, their historical significance, and summarize the recent progress in the field of deaminative transformations using these reagents.
