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  Arterial spin labeling in the hybrid PET/MRI workup of dementia patients

Barthel, H., Werner, P., Rullmann, M., Mildner, T., Jochimsen, T., Tiepolt, S., Gertz, H.-J., Schroeter, M. L., Saur, D., Möller, H. E., & Sabri, O. (2017). Arterial spin labeling in the hybrid PET/MRI workup of dementia patients. Journal of Cerebral Blood Flow and Metabolism, 37(Suppl. 1):, 157-158. doi:10.1177/0271678X17695982.

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アイテムのパーマリンク: https://hdl.handle.net/21.11116/0000-0004-F89B-6 版のパーマリンク: https://hdl.handle.net/21.11116/0000-0004-F89C-5
資料種別: 会議抄録

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作成者

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 作成者:
Barthel, H.1, 著者
Werner, P.1, 著者
Rullmann, M.1, 著者
Mildner, Toralf2, 著者           
Jochimsen, T.1, 著者
Tiepolt, S.1, 著者
Gertz, H.-J.1, 著者
Schroeter, Matthias L.1, 著者           
Saur, D.1, 著者
Möller, Harald E.2, 著者           
Sabri, O.1, 著者
所属:
1External Organizations, ou_persistent22              
2Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              

内容説明

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 要旨: Biomarkers are increasingly employed to supplement clinical diagnosis of Alzheimer's disease (AD). For that purpose, amyloid pathology and neuronal injury biomarkers are used. However, so far it was not possible to derive biomarkers of both categories within one imaging session. This project investigated the respective potential of arterial spin labeling (ASL) within simultaneous PET/MRI protocols.

Two scenarios were explored: (1) 37 patients (67 ± 9 yrs, 16 female) with cognitive and/or movement symptoms, simultaneous [18F]FDG brain PET/ASL MRI (Siemens 3T mMR). ASL: PICORE Q2TIPS, 18 slices a 4 mm in 64 × 64 matrix, TE/TI/TR = 16/ 2400 / 3400 ms, 55–60 min p.i.. (2) 65 subjects (68 ± 10 yrs, 31 female) with cognitive deficits, simultaneous [18F]Florbetaben amyloid PET/ASL MRI. Image data analysis: Visual (image quality, binary judgment: normal/abnormal, pattern recognition), VOI-based (AAL template, PMOD), and voxel-based (SPM).

70 % (1) and 68 % (2) of the ASL images were visually judged as of appropriate quality for further analysis. Of the remaining image pairs, in (1), binary visual ASL analysis had an extrapolated specificity and specificity of 72 % and 88 %, respectively, as compared to [18F]FDG. Signal distribution pattern was matched between ASL and [18F]FDG in 65 % of the cases. VOI-based analysis showed a positive correlation between rCBF and rCMRGlu in 29/70 cortical and subcortical VOIs. Of the remaining cases in (2) with pathological amyloid PET images, 79 % had AD patterns in ASL MRI, while 53/17/30 % of the remaining cases with normal amyloid PET images had normal/FTLD/AD patterns in ASL MRI. SPM analysis confirmed these ASL MRI differences.

In conclusion, more work is needed to improve data quality of ASL MRI, especially to derive individual diagnostic quality. Then, ASL MRI might have the potential of providing [18F]FDG-like biomarker information, an opportunity which is of special interest for combined amyloid PET/MRI in which differential dementia diagnosis solely based on the amyloid information is limited.

資料詳細

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言語: eng - English
 日付: 2017-04-01
 出版の状態: オンラインで出版済み
 ページ: -
 出版情報: -
 目次: -
 査読: -
 識別子(DOI, ISBNなど): DOI: 10.1177/0271678X17695982
PMID: 28366130
 学位: -

関連イベント

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イベント名: 28th International Symposium on Cerebral Blood Flow, Metabolism and Function / 13th International Conference on Quantification of Brain Function with PET
開催地: Berlin
開始日・終了日: 2017-04-01 - 2017-04-01

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出版物 1

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出版物名: Journal of Cerebral Blood Flow and Metabolism
種別: 学術雑誌
 著者・編者:
所属:
出版社, 出版地: New York : Lippincott Williams & Wilkins
ページ: - 巻号: 37 (Suppl. 1) 通巻号: PS01-095 開始・終了ページ: 157 - 158 識別子(ISBN, ISSN, DOIなど): ISSN: 0271-678X
CoNE: https://pure.mpg.de/cone/journals/resource/954925503202