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  Epigenetic dynamics in infancy and the impact of maternal engagement

Krol, K. M., Moulder, R. G., Lillard, T. S., Grossmann, T., & Connelly, J. J. (2019). Epigenetic dynamics in infancy and the impact of maternal engagement. Science Advances, 5(10): eaay0680. doi:10.1126/sciadv.aay0680.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0004-F6B2-D Version Permalink: https://hdl.handle.net/21.11116/0000-0005-AA16-3
Genre: Journal Article

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Krol_Moulder_2019.pdf (Publisher version), 352KB
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 Creators:
Krol, K. M.1, 2, Author           
Moulder, Robert G.1, Author
Lillard, Travis S.1, Author
Grossmann, Tobias1, 2, Author           
Connelly, Jessica J.1, Author
Affiliations:
1Department of Psychology, University of Virginia, Charlottesville, VA, USA, ou_persistent22              
2Max Planck Research Group Early Social Development, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_1356545              

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 Abstract: The contribution of nature versus nurture to the development of human behavior has been debated for centuries. Here, we offer a piece to this complex puzzle by identifying the human endogenous oxytocin system—known for its critical role in mammalian sociality—as a system sensitive to its early environment and subject to epigenetic change. Recent animal work suggests that early parental care is associated with changes in DNA methylation of conserved regulatory sites within the oxytocin receptor gene (OXTRm). Through dyadic modeling of behavior and OXTRm status across the first year and a half of life, we translated these findings to 101 human mother-infant dyads. We show that OXTRm is dynamic in infancy and its change is predicted by maternal engagement and reflective of behavioral temperament. We provide evidence for an early window of environmental epigenetic regulation of the oxytocin system, facilitating the emergence of individual differences in human behavior.

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Language(s): eng - English
 Dates: 2019-05-162019-09-222019-10-16
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1126/sciadv.aay0680
Other: eCollection 2019
PMID: 31663028
PMC: PMC6795517
 Degree: -

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Funding organization : Max Planck Society
Project name : Epigenetic influences on the early development of social brain functions
Grant ID : 1729289
Funding program : -
Funding organization : University of Virginia and National Science Foundation (NSF)
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Funding organization : International Max Planck Research School on Neuroscience of Communication: Function, Structure, and Plasticity (IMPRS NeuroCom)
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Funding program : Hartwell Biomedical Research Fellowship
Funding organization : The Hartwell Foundation
Project name : Institutional National Research Service Award (NRSA) / T32
Grant ID : -
Funding program : -
Funding organization : The National Institute of Diabetes and Digestive and Kidney Diseases

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Title: Science Advances
  Other : Sci. Adv.
Source Genre: Journal
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Publ. Info: Washington : AAAS
Pages: - Volume / Issue: 5 (10) Sequence Number: eaay0680 Start / End Page: - Identifier: ISSN: 2375-2548
CoNE: https://pure.mpg.de/cone/journals/resource/2375-2548