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  Translating a Low‐Molecular‐Weight MRI Probe Sensitive to Amino Acid Neurotransmitters into a PAMAM Dendrimer Conjugate: The Impact of Conjugation

Toljić, Đ., & Angelovski, G. (2019). Translating a Low‐Molecular‐Weight MRI Probe Sensitive to Amino Acid Neurotransmitters into a PAMAM Dendrimer Conjugate: The Impact of Conjugation. ChemNanoMat, 5(12), 1456-1460. doi:10.1002/cnma.201900552.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0004-F6D5-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-5875-5
Genre: Journal Article

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Toljić, Đ1, 2, Author              
Angelovski, G1, 2, Author              
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528691              

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 Abstract: A novel nano‐sized MRI probe sensitive to zwitterionic amino acid neurotransmitters (ZNTs) was prepared by the conjugation of bismacrocyclic ZNT‐responsive units to a generation 4 (G4) polyamidoamine (PAMAM) dendrimer. In vitro evaluation through 1H NMR relaxometric titrations provided binding profiles revealing a surface morphology‐dependent interaction with the ZNTs. The positively charged dendrimeric periphery gave higher initial relaxivities and a milder decrease upon interaction with the target molecules. To improve solubility under physiologically relevant conditions, polyethylene glycol (PEG) units were additionally conjugated to the dendrimeric surface. The PEGylated conjugate displayed discrimination towards acetylcholine and a slightly increased binding affinity towards glutamate over the massively abundant competitive metabolite hydrogencarbonate.

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 Dates: 2019-102019-12
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1002/cnma.201900552
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Title: ChemNanoMat
  Other : ChemNanoMat: chemistry of nanomaterials for energy, biology and more
  Abbreviation : ChemNanoMat
Source Genre: Journal
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Publ. Info: Weinheim : Wiley
Pages: - Volume / Issue: 5 (12) Sequence Number: - Start / End Page: 1456 - 1460 Identifier: ISSN: 2199-692X
CoNE: https://pure.mpg.de/cone/journals/resource/2199692X