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  Multiscale (re)modeling of lipid bilayer membranes

Grafmüller, A. (2019). Multiscale (re)modeling of lipid bilayer membranes. In Advances in Biomembranes and Lipid Self-Assembly (pp. 39-104). Amsterdam: Elsevier B.V. doi:10.1016/bs.abl.2019.09.002.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-168F-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-E4F8-2
Genre: Book Chapter

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 Creators:
Grafmüller, Andrea1, Author              
Affiliations:
1Andrea Grafmüller, Theorie & Bio-Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863323              

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Free keywords: Membrane remodeling, Multiscale modeling, Molecular simulation, Forcefields, Coarse grained lipids, Fusion, Budding, Pore formation, Reaction coordinate
 Abstract: Many phenomena of biological membranes are inherently multi-scalar: their observation and description requires very different length and time-scales. Especially membrane remodeling processes that are essential for many important cellular activities, such as endo- and exocytosis, cell division, infection, immune response or cell-cell communication, involve large scale morphological changes of the membrane, which are initiated and controlled by molecular scale interactions. The large-scale behavior of the membrane is intimately coupled to the atomic detail of the system, so that for a successful model, the contributions at all scales have to be included. This chapter gives an overview of the computational methods used to model lipid bilayer membranes and their interactions with proteins and other molecules at different levels of resolution. Then strategies to connect the models at different scales in order to provide a multi-resolution picture are described. Methods to quantify free energy changes associated with complex collective rearrangement are outlined. The last sections summarize examples for the application of these methods to pore formation, reshaping membranes into buds and membrane tubes as well as membrane fusion.

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Language(s): eng - English
 Dates: 2019-04-112019
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1016/bs.abl.2019.09.002
BibTex Citekey: GRAFMULLER2019
 Degree: -

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Title: Advances in Biomembranes and Lipid Self-Assembly
Source Genre: Series
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Publ. Info: Amsterdam : Elsevier B.V.
Pages: - Volume / Issue: 30 Sequence Number: - Start / End Page: 39 - 104 Identifier: ISSN: 2541-9634