English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  High spatiotemporal vessel-specific hemodynamic mapping with multi-echo single-vessel fMRI

He, Y., Wang, M., & Yu, X. (2020). High spatiotemporal vessel-specific hemodynamic mapping with multi-echo single-vessel fMRI. Journal of Cerebral Blood Flow and Metabolism, 40(10), 2098-2114. doi:10.1177/0271678X19886240.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0005-0E96-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0007-1BDE-2
Genre: Journal Article

Files

show Files

Locators

show
hide
Description:
-

Creators

show
hide
 Creators:
He, Y1, 2, Author              
Wang, M1, 2, Author              
Yu, X1, 2, Author              
Affiliations:
1Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528695              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

Content

show
hide
Free keywords: -
 Abstract: High-resolution fMRI enables noninvasive mapping of the hemodynamic responses from individual penetrating vessels in animal brains. Here, a 2D multi-echo single-vessel fMRI (MESV-fMRI) method has been developed to map the fMRI signal from arterioles and venules with a 100 ms sampling rate at multiple echo times (TE, 3–30 ms) and short acquisition windows (<1 ms). The T2*-weighted signal shows the increased extravascular effect on venule voxels as a function of TE. In contrast, the arteriole voxels show an increased fMRI signal with earlier onset than venules voxels at the short TE (3 ms) with increased blood inflow and volume effects. MESV-fMRI enables vessel-specific T2* mapping and presents T2*-based fMRI time courses with higher contrast-to-noise ratios (CNRs) than the T2*-weighted fMRI signal at a given TE. The vessel-specific T2* mapping also allows semi-quantitative estimation of the oxygen saturation levels (Y) and their changes (ΔY) at a given blood volume fraction upon neuronal activation. The MESV-fMRI method enables vessel-specific T2* measurements with high spatiotemporal resolution for better modeling of the fMRI signal based on the hemodynamic parameters.

Details

show
hide
Language(s):
 Dates: 2019-112020-10
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1177/0271678X19886240
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Journal of Cerebral Blood Flow and Metabolism
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York : Lippincott Williams & Wilkins
Pages: - Volume / Issue: 40 (10) Sequence Number: - Start / End Page: 2098 - 2114 Identifier: ISSN: 0271-678X
CoNE: https://pure.mpg.de/cone/journals/resource/954925503202