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  Cortico-brainstem mechanisms of biased perceptual decision-making in the context of pain

Wiech, K., Eippert, F., Vandekerckhove, J., Zaman, J., Placek, K., Tuerlinckx, F., et al. (2022). Cortico-brainstem mechanisms of biased perceptual decision-making in the context of pain. The Journal of Pain, 23(4), 680-692. doi:10.1016/j.jpain.2021.11.006.

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 Creators:
Wiech, Katja1, Author
Eippert, Falk2, Author           
Vandekerckhove, Joachim3, Author
Zaman, Jonas4, Author
Placek, Katerina5, Author
Tuerlinckx, Francis6, Author
Vlayen, Johan4, Author
Tracey, Irene1, Author
Affiliations:
1Nuffield Department Clinical Neurosciences, FMRIB Centre, University of Oxford, United Kingdom, ou_persistent22              
2Max Planck Research Group Pain Perception, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_2497695              
3Department of Cognitive Sciences, University of California, Irvine, CA, USA, ou_persistent22              
4Research Group Health Psychology, Katholieke Universiteit Leuven, Belgium, ou_persistent22              
5Takeda Pharmaceuticals, Statistics and Quantitative Sciences, Cambridge MA, USA, ou_persistent22              
6Research Group of Quantitative Psychology and Individual Differences, Katholieke Universiteit Leuven, Belgium, ou_persistent22              

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Free keywords: Amygdala; Bias; Expectation; Perceptual decision-making; Periaqueductal gray; Prefrontal
 Abstract: Perceptual decision-making is commonly studied using stimuli with different physical properties but of comparable affective value. Here, we investigate neural processes underlying human perceptual decisions in the affectively rich domain of pain using a drift-diffusion model in combination with a probabilistic cueing paradigm. This allowed us to characterize a novel role for the dorsolateral prefrontal cortex (DLPFC), whose anticipatory responses reflecting a decision bias were dependent on the affective value of the stimulus. During intense noxious stimulation, these model-based anticipatory DLPFC responses were linked to an engagement of the periaqueductal gray (PAG), a midbrain region implicated in defensive responses including analgesia. Complementing these findings on biased decision-making, the model parameter reflecting sensory processing predicted subcortical responses (in amygdala and PAG) when expectations were violated. Our findings highlight the importance of taking a broader perspective on perceptual decisions and link decisions about pain with subcortical circuitry implicated in endogenous pain modulation.

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Language(s): eng - English
 Dates: 2021-10-292021-06-032021-11-162021-11-282022-04
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.jpain.2021.11.006
Other: epub 2021
PMID: 34856408
 Degree: -

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Title: The Journal of Pain
Source Genre: Journal
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Publ. Info: New York : Elsevier
Pages: - Volume / Issue: 23 (4) Sequence Number: - Start / End Page: 680 - 692 Identifier: ISSN: 1526-5900
CoNE: https://pure.mpg.de/cone/journals/resource/1526-5900