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  No basal or drug-induced sex differences in striatal dopaminergic levels: a cluster and meta-analysis of rat microdialysis studies

Egenrieder, L., Mitricheva, E., Spanagel, R., & Noori, H. (2019). No basal or drug-induced sex differences in striatal dopaminergic levels: a cluster and meta-analysis of rat microdialysis studies. Journal of Neurochemistry, Epub ahead. doi:10.1111/jnc.14911.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-0FED-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-0FEE-0
Genre: Journal Article

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Egenrieder, L, Author
Mitricheva, E1, 2, Author              
Spanagel, R, Author
Noori, HR1, 2, Author              
Affiliations:
1Research Group Neuronal Convergence, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528694              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: Sex differences in behavioural patterns of drug abuse and dependence have been hypothesized to be a consequence of sexual dimorphisms in brain pathways, particularly within the dopaminergic reward circuitry. Yet, how potential sex differences are manifested at a neurochemical level remains unclear. Here, we use a meta-analysis approach to investigate whether animal studies robustly indicate a different regulation of striatal dopamine transmission in males and females. Data from 39 microdialysis experiments on female rats (n = 676) were extracted and statistically compared with data from 1,523 male rats. All drugs of abuse, independent of their molecular mechanisms of action, notably increase extracellular dopamine concentrations in the nucleus accumbens (NAc) and caudate putamen (CPu). No significant sex differences in basal levels or in dopaminergic response to drugs of abuse were found. However, basal dopamine levels in CPu (but not NAc) were significantly altered by ovariectomy. In conclusion, there are no sex-dependent differences in basal dopamine levels within the NAc and CPu. Previously reported sex differences in the CPu seem to be a result of ovariectomy and may only to a lesser, non-significant degree be attributed to a sexual duality.

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 Dates: 2019-11
 Publication Status: Published online
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 Identifiers: DOI: 10.1111/jnc.14911
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Title: Journal of Neurochemistry
  Other : J. Neurochem.
Source Genre: Journal
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Publ. Info: New York : Raven Press [etc.]
Pages: - Volume / Issue: Epub ahead Sequence Number: - Start / End Page: - Identifier: ISSN: 0022-3042
CoNE: https://pure.mpg.de/cone/journals/resource/954925416956_1