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  Brain-wide neuronal dynamics during motor adaptation in zebrafish

Ahrens, M., Li, J., Orger, M., Robson, D., Schier, A., Engert, F., et al. (2012). Brain-wide neuronal dynamics during motor adaptation in zebrafish. Nature, 485(7399), 471-477. doi:10.1038/nature11057.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-1A56-E Version Permalink: http://hdl.handle.net/21.11116/0000-0005-1A57-D
Genre: Journal Article

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Ahrens, MB, Author
Li, JM1, Author              
Orger, MB, Author
Robson, DN1, Author              
Schier, AF, Author
Engert, F, Author
Portugues, R, Author
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1External Organizations, ou_persistent22              

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 Abstract: A fundamental question in neuroscience is how entire neural circuits generate behaviour and adapt it to changes in sensory feedback. Here we use two-photon calcium imaging to record the activity of large populations of neurons at the cellular level, throughout the brain of larval zebrafish expressing a genetically encoded calcium sensor, while the paralysed animals interact fictively with a virtual environment and rapidly adapt their motor output to changes in visual feedback. We decompose the network dynamics involved in adaptive locomotion into four types of neuronal response properties, and provide anatomical maps of the corresponding sites. A subset of these signals occurred during behavioural adjustments and are candidates for the functional elements that drive motor learning. Lesions to the inferior olive indicate a specific functional role for olivocerebellar circuitry in adaptive locomotion. This study enables the analysis of brain-wide dynamics at single-cell resolution during behaviour.

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 Dates: 2012-05
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1038/nature11057
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Title: Nature
  Abbreviation : Nature
Source Genre: Journal
 Creator(s):
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 485 (7399) Sequence Number: - Start / End Page: 471 - 477 Identifier: Other: 1476-4687
ISSN: 0028-0836
CoNE: https://pure.mpg.de/cone/journals/resource/954925427238