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Free keywords:
anti-cholesterol; triterpenoid acids; pirdot; Saurauia vulcani Korth; Actinidiaceae
Abstract:
Two triterpenoid compounds, 3 beta-hydroxy-Olean-12-en- 28-oic acid (1)
and 3,19-Dihydroxyurs-12-en-28-oic acid (2) were isolated from the
leaves of Saurauia vulcani Korth. (Actinidiaceae). The chemical
structures of compounds 1-2 were elucidated with spectroscopic data (UV,
IR, H-1, C-13, DEPT 135o, HMQC, HMBC, H-1-H-1 COSY NMR) and MS as well
as compared with previously reported spectra data. All the compounds
were evaluated for their anti-cholesterol activity by the
Liebermann-Burchard (LB) colorimetric assay. Compound 1-2 showed a
remarkable anti-cholesterol activity. Most importantly, the raised
concentration of 1-2 exhibited a dose-dependent manner. The discoveries
of anti-cholesterol compounds 1-2 were first reported.
