English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Haematopoietic stem cells in perisinusoidal niches are protected from ageing

Saçma, M., Pospiech, J., Bogeska, R., de Back, W., Mallm, J.-P., Sakk, V., et al. (2019). Haematopoietic stem cells in perisinusoidal niches are protected from ageing. Nature Cell Biology, 21, 1309-1320. doi:10.1038/s41556-019-0418-y.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0005-1C26-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-1C27-1
Genre: Journal Article

Files

show Files
hide Files
:
Sacma et al..pdf (Publisher version), 27MB
Name:
Sacma et al..pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Saçma, Mehmet1, Author
Pospiech, Johannes1, Author
Bogeska, Ruzhica1, Author
de Back, Walter1, Author
Mallm, Jan-Philipp1, Author
Sakk, Vadim1, Author
Soller, Karin1, Author
Marka, Gina1, Author
Vollmer, Angelika1, Author
Karns, Rebekah1, Author
Cabezas-Wallscheid, Nina2, Author              
Trumpp, Andreas1, Author
Méndez-Ferrer, Simón1, Author
Milsom, Michael D.1, Author
Mulaw, Medhanie A.1, Author
&, Hartmut Geiger1, Author
Florian, Maria Carolina1, Author
Affiliations:
1External Organizations, ou_persistent22              
2Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, ou_2243641              

Content

show
hide
Free keywords: -
 Abstract: With ageing, intrinsic haematopoietic stem cell (HSC) activity decreases, resulting in impaired tissue homeostasis, reduced engraftment following transplantation and increased susceptibility to diseases. However, whether ageing also affects the HSC niche, and thereby impairs its capacity to support HSC function, is still widely debated. Here, by using in-vivo long-term label-retention assays we demonstrate that aged label-retaining HSCs, which are, in old mice, the most quiescent HSC subpopulation with the highest regenerative capacity and cellular polarity, reside predominantly in perisinusoidal niches. Furthermore, we demonstrate that sinusoidal niches are uniquely preserved in shape, morphology and number on ageing. Finally, we show that myeloablative chemotherapy can selectively disrupt aged sinusoidal niches in the long term, which is linked to the lack of recovery of endothelial Jag2 at sinusoids. Overall, our data characterize the functional alterations of the aged HSC niche and unveil that perisinusoidal niches are uniquely preserved and thereby protect HSCs from ageing.

Details

show
hide
Language(s): eng - English
 Dates: 2019-11-04
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1038/s41556-019-0418-y
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Nature Cell Biology
  Other : 'Nat. Cell Biol.'
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: London : Macmillan Magazines Ltd.
Pages: - Volume / Issue: 21 Sequence Number: - Start / End Page: 1309 - 1320 Identifier: ISSN: 1465-7392
CoNE: https://pure.mpg.de/cone/journals/resource/954925625310