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  Lateral subunit coupling determines intermediate filament mechanics

Lorenz, C., Forsting, J., Schepers, A. V., Kraxner, J., Bauch, S., Witt, H., et al. (2019). Lateral subunit coupling determines intermediate filament mechanics. Physical Review Letters, 123(18): 188102. doi:10.1103/PhysRevLett.123.188102.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-1DE5-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-1DE6-8
Genre: Journal Article

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Lorenz, C., Author
Forsting, J., Author
Schepers, A. V., Author
Kraxner, J., Author
Bauch, S., Author
Witt, Hannes1, Author              
Klumpp, S., Author
Köster, S., Author
Affiliations:
1Max Planck Fellow Group Membrane-based biomimetic nano- and micro-compartments, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society, ou_2586691              

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 Abstract: The cytoskeleton is a composite network of three types of protein filaments, among which intermediate filaments (IFs) are the most extensible ones. Two very important IFs are keratin and vimentin, which have similar molecular architectures but different mechanical behaviors. Here we compare the mechanical response of single keratin and vimentin filaments using optical tweezers. We show that the mechanics of vimentin strongly depends on the ionic strength of the buffer and that its force-strain curve suggests a high degree of cooperativity between subunits. Indeed, a computational model indicates that in contrast to keratin, vimentin is characterized by strong lateral subunit coupling of its charged monomers during unfolding of a helices. We conclude that cells can tune their mechanics by differential use of keratin versus vimentin.

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Language(s): eng - English
 Dates: 2019-10-292019-11-01
 Publication Status: Published in print
 Pages: -
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 Rev. Method: Peer
 Identifiers: DOI: 10.1103/PhysRevLett.123.188102
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Title: Physical Review Letters
Source Genre: Journal
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Pages: - Volume / Issue: 123 (18) Sequence Number: 188102 Start / End Page: - Identifier: -