English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  A nonlinear oscillator coordinates brain-wide motivational state during foraging

Li, J., Robson, D., Li, M., Marques, J., & Schaak, D. (2019). A nonlinear oscillator coordinates brain-wide motivational state during foraging. IBRO Reports, 6(Supplement): S35.04, S48.

Item is

Basic

show hide
Genre: Meeting Abstract

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Li, J1, Author              
Robson, D1, Author              
Li, M1, Author              
Marques, J, Author
Schaak, D, Author
Affiliations:
1External Organizations, ou_persistent22              

Content

show
hide
Free keywords: -
 Abstract: The motivational state of an animal sets its behavioral priorities and modulates its motor performance. In complex tasks such as foraging, internal state is dynamic, and behavior alternates between local search (exploitation) and global dispersal (exploration). It is unclear whether exploitation and exploration states are maintained by a specific set of master regulatory neurons or are emergent from large-scale population activity. Using tracking microscopy, we simultaneously imaged behavior and whole brain neural activity at cellular resolution in freely swimming zebrafish for hours during foraging behavior. We uncover a dorsal raphe subpopulation with persistent activity that encodes the exploitation state. The exploitation state-encoding neurons, together with a multimodal trigger network that is associated with state transitions, forms a stochastic nonlinear relaxation oscillator. The activity of this oscillatory network correlates with a global re-tuning of sensorimotor transformations during foraging that leads to dramatic changes in both the motivation to hunt for prey and the accuracy of motor sequences during hunting. This work reveals an important hidden variable that shapes the temporal structure of motivation and decision making.

Details

show
hide
Language(s):
 Dates: 2019-09
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.ibror.2019.07.147
 Degree: -

Event

show
hide
Title: 10th IBRO World Congress of Neuroscience (IBRO 2019): Joint Meeting of International Brain Research Organization & Federation of Asian-Oceanian Neuroscience Societies
Place of Event: Daegu, South Korea
Start-/End Date: 2019-09-21 - 2019-09-25

Legal Case

show

Project information

show

Source 1

show
hide
Title: IBRO Reports
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Elsevier
Pages: - Volume / Issue: 6 (Supplement) Sequence Number: S35.04 Start / End Page: S48 Identifier: ISSN: 2451-8301