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  Real-time monitoring of solid-phase peptide synthesis using a variable bed glow reactor

Sletten, E. T., Nuno, M., Guthrie, D., & Seeberger, P. H. (2019). Real-time monitoring of solid-phase peptide synthesis using a variable bed glow reactor. Chemical Communications, 55(97), 14598-14601. doi:10.1039/C9CC08421E.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-3E5F-D Version Permalink: http://hdl.handle.net/21.11116/0000-0006-56BA-8
Genre: Journal Article

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 Creators:
Sletten, Eric T.1, Author              
Nuno, Manuel, Author
Guthrie, Duncan, Author
Seeberger, Peter H.1, Author              
Affiliations:
1Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863306              

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 Abstract: On-resin aggregation and incomplete amide bond formation are major challenges for solid-phase peptide synthesis that are difficult to be monitored in real-time. Incorporation of a pressure-based variable bed flow reactor into an automated solid-phase peptide synthesizer permitted real-time monitoring of resin swelling to determine amino acid coupling efficiency and on-resin aggregation.

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Language(s): eng - English
 Dates: 2019-11-112019
 Publication Status: Published in print
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 Rev. Method: -
 Identifiers: DOI: 10.1039/C9CC08421E
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Title: Chemical Communications
  Other : Chem. Commun.
Source Genre: Journal
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Publ. Info: Cambridge, UK : Royal Society of Chemistry
Pages: - Volume / Issue: 55 (97) Sequence Number: - Start / End Page: 14598 - 14601 Identifier: ISSN: 1359-7345