hide
Free keywords:
Schwann cells, Axons, Peripheral nerve
Abstract:
During the development of the peripheral nervous system, axons and
myelinating Schwann cells form a unique symbiotic unit, which is
realized by a finely tuned network of molecular signals and reciprocal
interactions. The importance of this complex interplay becomes evident
after injury or in diseases in which aspects of axo-glial interaction are
perturbed. This Review focuses on the specific interdependence of
axons and Schwann cells in peripheral nerve development that enables
axonal outgrowth, Schwann cell lineage progression, radial sorting and,
finally, formation and maintenance of the myelin sheath.
