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  Mapping microglia states in the human brain through the integration of high-dimensional techniques

Sankowski, R., Böttcher, C., Masuda, T., Geirsdottir, L., Sagar, S., Sindram, E., et al. (2019). Mapping microglia states in the human brain through the integration of high-dimensional techniques. Nature Neuroscience, 22, 2098-2110. doi:org/10-1038/s41593-019-0532-y.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-98C8-E Version Permalink: http://hdl.handle.net/21.11116/0000-0005-98C9-D
Genre: Journal Article

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 Creators:
Sankowski, Roman1, Author
Böttcher, Chotima1, Author
Masuda, Takahiro1, Author
Geirsdottir, Laufey1, Author
Sagar, Sagar2, Author
Sindram, Elena1, Author
Seredenina, Tamara1, Author
Muhs, Andreas1, Author
Scheiwe, Christian1, Author
Shah, Mukesch Johannes1, Author
Heiland, Dieter Henrik1, Author
Schnell, Oliver1, Author
Grün, Dominic2, Author              
Priller, Josef1, Author
Prinz, Marco1, Author
Affiliations:
1External Organizations, ou_persistent22              
2Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243642              

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 Abstract: Microglia are tissue-resident macrophages of the CNS that orchestrate local immune responses and contribute to several neurological and psychiatric diseases. Little is known about human microglia and how they orchestrate their highly plastic, context-specific adaptive responses during pathology. Here we combined two high-dimensional technologies, single-cell RNAsequencing and time-of-flight mass cytometry, to identify microglia states in the human brain during homeostasis and disease. This approach enabled us to identify and characterize a previously unappreciated spectrum of transcriptional states in human microglia. These transcriptional states are determined by their spatial distribution, and they further change with aging and brain tumor pathology. This description of multiple microglia phenotypes in the human CNS may open promising new avenues for subset-specific therapeutic interventions.

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Language(s): eng - English
 Dates: 2019-11-182019
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: org/10-1038/s41593-019-0532-y
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Title: Nature Neuroscience
  Other : Nat. Neurosci.
Source Genre: Journal
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Publ. Info: New York, NY : Nature America Inc.
Pages: - Volume / Issue: 22 Sequence Number: - Start / End Page: 2098 - 2110 Identifier: ISSN: 1097-6256
CoNE: https://pure.mpg.de/cone/journals/resource/954925610931