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  Intracellular distribution of DNA topoisomerase I in fibroblasts from patients with Fanconi's anaemia

Auer, B., Vosberg, H.-P., Buhre, U., Klocker, H., Hirsch-Kauffmann, M., & Schweiger, M. (1982). Intracellular distribution of DNA topoisomerase I in fibroblasts from patients with Fanconi's anaemia. Human Genetics, 61(4), 369-371. doi:10.1007/BF00276603.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0005-39C4-E Version Permalink: https://hdl.handle.net/21.11116/0000-0005-39C5-D
Genre: Journal Article

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HumanGenet_61_1983_369.pdf (Any fulltext), 388KB
 
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https://link.springer.com/content/pdf/10.1007%2FBF00276603.pdf (Any fulltext)
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 Creators:
Auer, Bernhard, Author
Vosberg, Hans-Peter1, Author           
Buhre, Ursula, Author
Klocker, Helmut, Author
Hirsch-Kauffmann, Monica, Author
Schweiger, Manfred, Author
Affiliations:
1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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Free keywords: Internal Medicine; Metabolic Disease; Fibroblast; Cell Nuclear; Extract Cellular Activity;
 Abstract: The activity of DNA topoisomerase I (DNA nicking-closing enzyme) was analysed in cytoplasmic and nuclear extracts of six independently derived Fanconi and four normal fibroblast cell lines. In all experiments the total cellular activity was predominantly found in the nuclear extracts (88–100%). In addition, a minor proportion of the enzyme (up to 12%) was randomly present in some of the cytoplasmic fractions of both Fanconi and normal fibroblasts. These results indicate that Fanconi's anaemia is probably not due to or accompanied by a maldistribution of topoisomerase I between nuclei and cytoplasm.

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Language(s): eng - English
 Dates: 1982-08-141982-05-081982-11
 Publication Status: Issued
 Pages: 3
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1007/BF00276603
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Title: Human Genetics
Source Genre: Journal
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Publ. Info: Berlin : Springer-Verlag
Pages: - Volume / Issue: 61 (4) Sequence Number: - Start / End Page: 369 - 371 Identifier: ISSN: 0340-6717
CoNE: https://pure.mpg.de/cone/journals/resource/954925519623