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  Chromosome errors in human eggs shape natural fertility over reproductive life span.

Gruhn, J. R., Zielinska, A., Shukla, V., Blanshard, R., Capalbo, A., Cimadomo, D., et al. (2019). Chromosome errors in human eggs shape natural fertility over reproductive life span. Science, 365(6460), 1466-1469. doi:10.1126/science.aav7321.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-3A5D-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-3A62-C
Genre: Journal Article

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 Creators:
Gruhn, J. R., Author
Zielinska, A.1, Author              
Shukla, V., Author
Blanshard, R., Author
Capalbo, A., Author
Cimadomo, D., Author
Nikiforov, D., Author
Chan, A. C., Author
Newnham, L. J., Author
Vogel, I., Author
Scarica, C., Author
Krapchev, M., Author
Taylor, D., Author
Kristensen, S. G., Author
Cheng, J., Author
Ernst, E., Author
Bjørn, A. M. B., Author
Colmorn, L. B., Author
Blayney, M., Author
Elder, K., Author
Liss, J., AuthorHartshorne, G., AuthorGrøndahl, M. L., AuthorRienzi, L., AuthorUbaldi, F., AuthorMcCoy, R., AuthorLukaszuk, K., AuthorAndersen, C. Y., AuthorSchuh, M.1, Author              Hoffmann, E. R., Author more..
Affiliations:
1Department of Meiosis, MPI for Biophysical Chemistry, Max Planck Society, ou_2205654              

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 Abstract: Chromosome errors, or aneuploidy, affect an exceptionally high number of human conceptions, causing pregnancy loss and congenital disorders. Here, we have followed chromosome segregation in human oocytes from females aged 9 to 43 years and report that aneuploidy follows a U-curve. Specific segregation error types show different age dependencies, providing a quantitative explanation for the U-curve. Whole-chromosome nondisjunction events are preferentially associated with increased aneuploidy in young girls, whereas centromeric and more extensive cohesion loss limit fertility as women age. Our findings suggest that chromosomal errors originating in oocytes determine the curve of natural fertility in humans.

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Language(s): eng - English
 Dates: 2019-09-27
 Publication Status: Published online
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 Rev. Method: Peer
 Identifiers: DOI: 10.1126/science.aav7321
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Title: Science
Source Genre: Journal
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Pages: - Volume / Issue: 365 (6460) Sequence Number: - Start / End Page: 1466 - 1469 Identifier: -