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  Binding and segregation of proteins in membrane adhesion: theory, modeling, and simulations

Weikl, T. R., Hu, J., Kav, B., & Różycki, B. (2019). Binding and segregation of proteins in membrane adhesion: theory, modeling, and simulations. Advances in Biomembranes and Lipid Self-Assembly, 30, 159-194. doi:10.1016/bs.abl.2019.10.004.

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 Creators:
Weikl, Thomas R.1, Author           
Hu, Jinglei, Author
Kav, Batuhan1, Author           
Różycki, Bartosz, Author
Affiliations:
1Thomas Weikl, Theorie & Bio-Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863330              

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Free keywords: Cell adhesion, Membrane bending energy, Membrane shape fluctuations, Protein binding, Binding cooperativity
 Abstract: The adhesion of biomembranes is mediated by the binding of membrane-anchored receptor and ligand proteins. The proteins can only bind if the separation between apposing membranes is sufficiently close to the length of the protein complexes, which leads to an interplay between protein binding and membrane shape. In this article, we review current models of biomembrane adhesion and novel insights obtained from the models. Theory and simulations with elastic-membrane and coarse-grained molecular models of biomembrane adhesion indicate that the binding of proteins in membrane adhesion strongly depends on nanoscale shape fluctuations of the apposing membranes, which results in binding cooperativity. A length mismatch between protein complexes leads to repulsive interactions that are caused by membrane bending and act as a driving force for the length-based segregation of proteins during membrane adhesion.

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Language(s): eng - English
 Dates: 2019-11-212019
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/bs.abl.2019.10.004
arXiv: 1911.09352
BibTex Citekey: WEIKL2019
Other: nicht als Buchkapitel aufnehmen
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Title: Advances in Biomembranes and Lipid Self-Assembly
Source Genre: Series
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Pages: - Volume / Issue: 30 Sequence Number: - Start / End Page: 159 - 194 Identifier: ISSN: 2451-9634

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Title: Multiresponsive Behavior of Biomembranes and Giant Vesicles
Source Genre: Book
 Creator(s):
Lipowsky, Reinhard1, Editor           
Affiliations:
1 Reinhard Lipowsky, Theorie & Bio-Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863327            
Publ. Info: Academic Press
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISBN: 978-012817483-8