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  Only vulnerable adults show change in chronic low-grade inflammation after contemplative mental training: Evidence randomized clinical trial

Puhlmann, L. M., Engert, V., Apostolakou, F., Papassotiriou, I., Chrousos, G. P., Vrticka, P., et al. (2019). Only vulnerable adults show change in chronic low-grade inflammation after contemplative mental training: Evidence randomized clinical trial. Scientific Reports, 9: 19323. doi:10.1038/s41598-019-55250-3.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-3DC1-D Version Permalink: http://hdl.handle.net/21.11116/0000-0005-7ADC-B
Genre: Journal Article

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 Creators:
Puhlmann, Lara M.1, Author              
Engert, Veronika1, 2, Author              
Apostolakou, Filia3, Author
Papassotiriou, Ioannes3, Author
Chrousos, George P.4, Author
Vrticka, Pascal1, Author              
Singer, Tania5, Author              
Affiliations:
1Research Group Social Stress and Family Health, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3025667              
2Department of Social Neuroscience, Institute of Psychosocial Medicine and Psychotherapy, Jena University Hospital, Germany, ou_persistent22              
3Department of Clinical Biochemistry, "Aghia Sofia" General Children's Hospital, Athens, Greece, ou_persistent22              
4First Department of Pediatrics, School of Medicine, "Aghia Sofia" General Children's Hospital, Athens, Greece, ou_persistent22              
5Social Neuroscience Lab, Berlin, Germany, ou_persistent22              

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Free keywords: Cytokines; Human behaviour; Predictive markers
 Abstract: Growing evidence suggests that chronic low-grade inflammation can be reduced through mindfulness-based mental training interventions. However, these results are inconsistent and based on patient populations with heterogeneous conditions. Similar research in healthy adults is lacking. Moreover, common intervention protocols involve varying combinations of different contemplative practices, such that it remains unclear which types of training most effectively influence biomarkers of inflammation. The present study investigated the effect of three distinct 3-month training modules cultivating a) interoception and present-moment focus (Presence), b) socio-affective skills (Affect), or c) socio-cognitive skills (Perspective) on the inflammatory biomarkers interleukin-6 (IL-6) and high sensitive C-reactive protein (hs-CRP) in 298 healthy adults. We observed no group-level effect of training on either biomarker, but trend-level interactions of training type and participant sex. In additionally exploring the influence of participants’ baseline inflammation, a selective training effect emerged: Following the Presence module, participants with relatively higher inflammatory load showed stronger reduction in IL-6 on average, and in hs-CRP if they were male. Mindfulness- and attention-based mental practice thus appears most effective when targeting chronic low-grade inflammation in healthy adults, particularly in men. Overall, our data point to a floor effect in the reduction of inflammatory markers through contemplative mental training, suggesting that mental training may be less effective in improving basal biological health outcomes in healthy, low-stressed adults than in vulnerable populations.

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Language(s): eng - English
 Dates: 2019-02-212019-11-062019-12-18
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1038/s41598-019-55250-3
PMID: 31852916
PMC: PMC6920474
 Degree: -

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Project name : Plasticity of the Empathic Brain: Structural and Functional MRI Studies on the Effect of Empathy Training on the Human Brain and Prosocial Behaviour /
Grant ID : 205557
Funding program : Funding Programme 7
Funding organization : European Commission (EC)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Max Planck Society

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Title: Scientific Reports
  Abbreviation : Sci. Rep.
Source Genre: Journal
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Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: 9 Sequence Number: 19323 Start / End Page: - Identifier: ISSN: 2045-2322
CoNE: https://pure.mpg.de/cone/journals/resource/2045-2322