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  Cervical cord neurodegeneration in traumatic and non-traumatic spinal cord injury

Seif, M., David, G., Huber, E., Vallotton, K., Curt, A., & Freund, P. (2019). Cervical cord neurodegeneration in traumatic and non-traumatic spinal cord injury. Journal of Neurotrauma. doi:10.1089/neu.2019.6694.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-0005-40CF-A Versions-Permalink: https://hdl.handle.net/21.11116/0000-0005-58DD-0
Genre: Zeitschriftenartikel

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 Urheber:
Seif, Maryam1, Autor
David, Gergely1, Autor
Huber, Eveline1, Autor
Vallotton, Kevin1, Autor
Curt, Armin1, Autor
Freund, Patrick1, 2, 3, 4, Autor           
Affiliations:
1Balgrist Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland, ou_persistent22              
2Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
3Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, United Kingdom, ou_persistent22              
4Department of Neurology, University Hospital Zurich, Switzerland, ou_persistent22              

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Schlagwörter: Biomarker; DCM; DTI; Quantitative MRI; Traumatic SCI
 Zusammenfassung: This study aimed to compare macrostructural and microstructural neurodegenerative changes remote from a cervical spinal cord injury in traumatic spinal cord injury (tSCI) and degenerative cervical myelopathy (DCM) patients using quantitative magnetic resonance imaging (MRI). Twenty-nine tSCI patients, 20 mild/moderate DCM patients, and 22 healthy controls underwent a high-resolution MRI protocol at the cervical cord (C2/C3). High-resolution T2*-weighted and diffusion-weighted scans provided data to calculate tissue-specific cross-sectional areas of the spinal cord and tract-specific diffusion indices of cord white matter, respectively. Regression analysis determined associations between neurodegeneration and clinical impairment. tSCI patients showed more impairment in upper limb strength and manual dexterity when compared with DCM patients. While macrostructural MRI measures revealed a similar extent of remote cord atrophy at cervical level, microstructural measures (diffusion indices) were able to distinguish more pronounced tract-specific neurodegeneration in tSCI patients when compared with DCM patients. Tract-specific neurodegeneration was associated with upper limb impairment. Despite clinical differences between severely impaired tSCI compared with mildly affected DCM patient, extensive cord atrophy is present remotely from the focal spinal cord injury. Diffusion indices revealed greater tract-specific alterations in tSCI patients. Therefore, diffusion indices are more sensitive than macrostructural MRI measures as these are able to distinguish between traumatic and non-traumatic spinal cord injury. Neuroimaging biomarkers of cervical cord integrity hold potential as predictors of recovery and might be suitable biomarkers for interventional trials both in traumatic and non-traumatic SCI.

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Sprache(n): eng - English
 Datum: 2019-09-212019-11-08
 Publikationsstatus: Online veröffentlicht
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1089/neu.2019.6694
Anderer: Epub ahead of print
PMID: 31544628
 Art des Abschluß: -

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Projektinformation

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Projektname : Entschlüsselung der pathophysiologischen Prozesse induziert durch eine Querschnittlähmung: Anwendung von MRT basierter in vivo und ex vivo Histologie / hMRIofSCI
Grant ID : 32NE30_173678
Förderprogramm : ERA-NET NEURON Call "Entwicklungsstörungen im Nervensystem"
Förderorganisation : German Federal Ministry of Education and Research (BMBF)
Projektname : Antibodies against Nogo-A to enhance plasticity, regeneration and functional recovery after acute spinal cord injury, a multicenter European clinical proof of concept trial / NISCI
Grant ID : 681094
Förderprogramm : Horizon 2020
Förderorganisation : European Commission (EC)
Projektname : -
Grant ID : 15.0137
Förderprogramm : -
Förderorganisation : Swiss State Secretariat for Education, Research and Innovation (SERI)
Projektname : -
Grant ID : WFL-CH-007/14
Förderprogramm : -
Förderorganisation : Wings for Life, Austria
Projektname : -
Grant ID : IRP-158
Förderprogramm : -
Förderorganisation : International Foundation for Research
Projektname : -
Grant ID : 181362
Förderprogramm : Eccellenza Fellowship
Förderorganisation : Swiss National Science Foundation (SNSF)
Projektname : -
Grant ID : 091593/Z/10/Z
Förderprogramm : -
Förderorganisation : Wellcome Trust

Quelle 1

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Titel: Journal of Neurotrauma
  Andere : J. Neurotrauma
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: New York, NY : M.A. Liebert
Seiten: - Band / Heft: - Artikelnummer: - Start- / Endseite: - Identifikator: ISSN: 0897-7151
CoNE: https://pure.mpg.de/cone/journals/resource/954925561573