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  Cervical cord neurodegeneration in traumatic and non-traumatic spinal cord injury

Seif, M., David, G., Huber, E., Vallotton, K., Curt, A., & Freund, P. (2020). Cervical cord neurodegeneration in traumatic and non-traumatic spinal cord injury. Journal of Neurotrauma, 37(6), 860-867. doi:10.1089/neu.2019.6694.

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アイテムのパーマリンク: https://hdl.handle.net/21.11116/0000-0005-40CF-A 版のパーマリンク: https://hdl.handle.net/21.11116/0000-000E-3E46-F
資料種別: 学術論文

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Seif_David_2019.pdf (出版社版), 504KB
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https://hdl.handle.net/21.11116/0000-0005-40D1-6
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Seif_David_2019.pdf
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https://creativecommons.org/licenses/by/4.0/

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作成者

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 作成者:
Seif, Maryam1, 著者
David, Gergely1, 著者
Huber, Eveline1, 著者
Vallotton, Kevin1, 著者
Curt, Armin1, 著者
Freund, Patrick1, 2, 3, 4, 著者           
所属:
1Balgrist Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland, ou_persistent22              
2Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
3Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, United Kingdom, ou_persistent22              
4Department of Neurology, University Hospital Zurich, Switzerland, ou_persistent22              

内容説明

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キーワード: Biomarker; DCM; DTI; Quantitative MRI; Traumatic SCI
 要旨: This study aimed to compare macrostructural and microstructural neurodegenerative changes remote from a cervical spinal cord injury in traumatic spinal cord injury (tSCI) and degenerative cervical myelopathy (DCM) patients using quantitative magnetic resonance imaging (MRI). Twenty-nine tSCI patients, 20 mild/moderate DCM patients, and 22 healthy controls underwent a high-resolution MRI protocol at the cervical cord (C2/C3). High-resolution T2*-weighted and diffusion-weighted scans provided data to calculate tissue-specific cross-sectional areas of the spinal cord and tract-specific diffusion indices of cord white matter, respectively. Regression analysis determined associations between neurodegeneration and clinical impairment. tSCI patients showed more impairment in upper limb strength and manual dexterity when compared with DCM patients. While macrostructural MRI measures revealed a similar extent of remote cord atrophy at cervical level, microstructural measures (diffusion indices) were able to distinguish more pronounced tract-specific neurodegeneration in tSCI patients when compared with DCM patients. Tract-specific neurodegeneration was associated with upper limb impairment. Despite clinical differences between severely impaired tSCI compared with mildly affected DCM patient, extensive cord atrophy is present remotely from the focal spinal cord injury. Diffusion indices revealed greater tract-specific alterations in tSCI patients. Therefore, diffusion indices are more sensitive than macrostructural MRI measures as these are able to distinguish between traumatic and non-traumatic spinal cord injury. Neuroimaging biomarkers of cervical cord integrity hold potential as predictors of recovery and might be suitable biomarkers for interventional trials both in traumatic and non-traumatic SCI.

資料詳細

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言語: eng - English
 日付: 2019-09-212019-11-082020-03-15
 出版の状態: 出版
 ページ: -
 出版情報: -
 目次: -
 査読: -
 識別子（DOI, ISBNなど）: DOI: 10.1089/neu.2019.6694
その他: Epub 2019
PMID: 31544628
 学位: -

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Project information

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Project name : Entschlüsselung der pathophysiologischen Prozesse induziert durch eine Querschnittlähmung: Anwendung von MRT basierter in vivo und ex vivo Histologie / hMRIofSCI
Grant ID : 32NE30_173678
Funding program : ERA-NET NEURON Call "Entwicklungsstörungen im Nervensystem"
Funding organization : German Federal Ministry of Education and Research (BMBF)
Project name : Antibodies against Nogo-A to enhance plasticity, regeneration and functional recovery after acute spinal cord injury, a multicenter European clinical proof of concept trial / NISCI
Grant ID : 681094
Funding program : Horizon 2020
Funding organization : European Commission (EC)
Project name : -
Grant ID : 15.0137
Funding program : -
Funding organization : Swiss State Secretariat for Education, Research and Innovation (SERI)
Project name : -
Grant ID : WFL-CH-007/14
Funding program : -
Funding organization : Wings for Life, Austria
Project name : -
Grant ID : IRP-158
Funding program : -
Funding organization : International Foundation for Research
Project name : -
Grant ID : 181362
Funding program : Eccellenza Fellowship
Funding organization : Swiss National Science Foundation (SNSF)
Project name : -
Grant ID : 091593/Z/10/Z
Funding program : -
Funding organization : Wellcome Trust

出版物 1

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出版物名: Journal of Neurotrauma
  その他 : J. Neurotrauma
種別: 学術雑誌
 著者・編者:
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出版社, 出版地: New York, NY : M.A. Liebert
ページ: - 巻号: 37 (6) 通巻号: - 開始・終了ページ: 860 - 867 識別子（ISBN, ISSN, DOIなど）: ISSN: 0897-7151
CoNE: https://pure.mpg.de/cone/journals/resource/954925561573