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  Prefrontal and posterior parietal contributions to the perceptual awareness of touch

Rullmann, M., Preusser, S., & Pleger, B. (2019). Prefrontal and posterior parietal contributions to the perceptual awareness of touch. Scientific Reports, 9: 16981. doi:10.1038/s41598-019-53637-w.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-43AB-F Version Permalink: http://hdl.handle.net/21.11116/0000-0005-58E8-3
Genre: Journal Article

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 Creators:
Rullmann, Michael1, 2, Author              
Preusser, Sven1, Author              
Pleger, Burkhard1, 3, 4, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Department of Nuclear Medicine, University of Leipzig, Germany, ou_persistent22              
3Department of Neurology, University Hospital Bergmannsheil, Bochum, Germany, ou_persistent22              
4Collaborative Research Centre 874 “Integration and Representation of Sensory Processes”, Ruhr University, Bochum, Germany, ou_persistent22              

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Free keywords: Brain; Sensory processing
 Abstract: Which brain regions contribute to the perceptual awareness of touch remains largely unclear. We collected structural magnetic resonance imaging scans and neurological examination reports of 70 patients with brain injuries or stroke in S1 extending into adjacent parietal, temporal or pre-/frontal regions. We applied voxel-based lesion-symptom mapping to identify brain areas that overlap with an impaired touch perception (i.e., hypoesthesia). As expected, patients with hypoesthesia (n = 43) presented lesions in all Brodmann areas in S1 on postcentral gyrus (BA 1, 2, 3a, 3b). At the anterior border to BA 3b, we additionally identified motor area BA 4p in association with hypoesthesia, as well as further ventrally the ventral premotor cortex (BA 6, BA 44), assumed to be involved in whole-body perception. At the posterior border to S1, we found hypoesthesia associated effects in attention-related areas such as the inferior parietal lobe and intraparietal sulcus. Downstream to S1, we replicated previously reported lesion-hypoesthesia associations in the parietal operculum and insular cortex (i.e., ventral pathway of somatosensory processing). The present findings extend this pathway from S1 to the insular cortex by prefrontal and posterior parietal areas involved in multisensory integration and attention processes.

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Language(s): eng - English
 Dates: 2019-07-052019-11-012019-11-18
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1038/s41598-019-53637-w
PMID: 31740713
PMC: PMC6861260
 Degree: -

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Project name : Integration and Representation of Sensory Processes / SFB 874
Grant ID : -
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft (DFG)
Project name : Bernstein Focus State Dependencies of Learning
Grant ID : 01GQ0971-5
Funding program : -
Funding organization : German Federal Ministry of Education and Research (BMBF)
Project name : Kompetenzcluster für Ernährung und kardiovaskuläre Gesundheit / nutriCARD
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Funding program : -
Funding organization : German Federal Ministry of Education and Research (BMBF)
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Grant ID : 01E01001
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Funding organization : IFB Adiposity Diseases, German Federal Ministry of Education and Research (BMBF)
Project name : Obesity Mechanisms / SFB 1052
Grant ID : -
Funding program : -
Funding organization : German Research Foundation (DFG)

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Title: Scientific Reports
  Abbreviation : Sci. Rep.
Source Genre: Journal
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Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: 9 Sequence Number: 16981 Start / End Page: - Identifier: ISSN: 2045-2322
CoNE: https://pure.mpg.de/cone/journals/resource/2045-2322