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  Cortical Output Is Gated by Horizontally Projecting Neurons in the Deep Layers

Egger, R., Narayanan, R. T., Guest, J. M., Bast, A., Udvary, D., Messore, L. F., et al. (2020). Cortical Output Is Gated by Horizontally Projecting Neurons in the Deep Layers. Neuron, 105: e8, pp. 122-137. doi:10.1016/j.neuron.2019.10.011.

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1-s2.0-S0896627319308840-main.pdf (Publisher version), 8MB
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 Creators:
Egger, Robert1, Author
Narayanan, Rajeevan T. 1, Author
Guest, Jason Mike1, Author              
Bast, Arco1, Author
Udvary, Daniel1, Author
Messore, Luis F.1, Author
Das, Suman2, Author
De Kock, Christiaan P.J.2, Author
Oberlaender, Marcel1, Author              
Affiliations:
1Max Planck Research Group In Silico Brain Sciences, Center of Advanced European Studies and Research (caesar), Max Planck Society, Ludwig-Erhard-Allee 2, 53175 Bonn, DE, ou_2333691              
2External Organizations, ou_persistent22              

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Free keywords: barrel cortex, pyramidal tract neurons, corticocortical neurons, synchrony, in silico
 Abstract: Pyramidal tract neurons (PTs) represent the major output cell type of the mammalian neocortex. Here, we report the origins of the PTs’ ability to respond to a broad range of stimuli with onset latencies that rival or even precede those of their intracortical input neurons. We find that neurons with extensive horizontally projecting axons cluster around the deep-layer terminal fields of primary thalamocortical axons. The strategic location of these corticocortical neurons results in high convergence of thalamocortical inputs, which drive reliable sensory-evoked responses that precede those in other excitatory cell types. The resultant fast and horizontal stream of excitation provides PTs throughout the cortical area with input that acts to amplify additional inputs from thalamocortical and other intracortical populations. The fast onsets and broadly tuned characteristics of PT responses hence reflect a gating mechanism in the deep layers, which assures that sensory-evoked input can be reliably transformed into cortical output.
 Abstract: In Brief: Egger, Narayanan, et al. describe the cellular and circuit mechanisms underlying the transformation of sensory-evoked thalamocortical input into fast and broadly tuned cortical output. The study provides a comprehensive multi-scale cortex model for studying streams of sensory-evoked excitationin silico.

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Language(s): eng - English
 Dates: 2019-11-262020-01-08
 Publication Status: Published in print
 Pages: -
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 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.neuron.2019.10.011
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Title: Neuron
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 105 Sequence Number: e8 Start / End Page: 122 - 137 Identifier: ISSN: 0896-6273
CoNE: https://pure.mpg.de/cone/journals/resource/954925560565