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  A CMOS NMR needle for probing brain physiology with high spatial and temporal resolution

Handwerker, J., Pérez-Rodas, M., Beyerlein, M., Vincent, F., Beck, A., Freytag, N., et al. (2020). A CMOS NMR needle for probing brain physiology with high spatial and temporal resolution. Nature methods, 17(1), 64-67. doi:10.1038/s41592-019-0640-3.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-4551-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-703C-A
Genre: Journal Article

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 Creators:
Handwerker, J, Author
Pérez-Rodas, M1, 2, Author              
Beyerlein, M2, 3, Author              
Vincent, F, Author
Beck, A, Author
Freytag, N, Author
Yu, X2, 4, Author              
Pohmann, R1, 2, Author              
Anders, J, Author
Scheffler, K1, 2, Author              
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
3Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
4Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528695              

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 Abstract: Magnetic resonance imaging and spectroscopy are versatile methods for probing brain physiology, but their intrinsically low sensitivity limits the achievable spatial and temporal resolution. Here, we introduce a monolithically integrated NMR-on-a-chip needle that combines an ultra-sensitive 300 µm NMR coil with a complete NMR transceiver, enabling in vivo measurements of blood oxygenation and flow in nanoliter volumes at a sampling rate of 200 Hz.

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 Dates: 2019-112020-01
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1038/s41592-019-0640-3
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Title: Nature methods
  Other : Nature methods
Source Genre: Journal
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Publ. Info: New York, NY : Nature Pub. Group
Pages: - Volume / Issue: 17 (1) Sequence Number: - Start / End Page: 64 - 67 Identifier: ISSN: 1548-7091
CoNE: https://pure.mpg.de/cone/journals/resource/111088195279556