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  Rapid detection of Salmonella enterica via directional emission from carbohydrate-functionalized dynamic double emulsions

Zeininger, L., Nagelberg, S., Harvey, K. S., Savagatrup, S., Herbert, M. B., Yoshinaga, K., et al. (2019). Rapid detection of Salmonella enterica via directional emission from carbohydrate-functionalized dynamic double emulsions. ACS Central Science, 5(5), 789-795. doi:10.1021/acscentsci.9b00059.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-4682-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-4683-8
Genre: Journal Article

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 Creators:
Zeininger, Lukas1, Author              
Nagelberg, Sara, Author
Harvey, Kent S., Author
Savagatrup, Suchol, Author
Herbert, Myles B., Author
Yoshinaga, Kosuke, Author
Capobianco, Joseph A., Author
Kolle, Mathias, Author
Swager, Timothy M., Author
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1External Organizations, ou_persistent22              

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 Abstract: Reliable early-stage detection of foodborne pathogens is a global public health challenge that requires new and improved sensing strategies. Here, we demonstrate that dynamically reconfigurable fluorescent double emulsions can function as highly responsive optical sensors for the rapid detection of carbohydrates fructose, glucose, mannose, and mannan, which are involved in many biological and pathogenic phenomena. The proposed detection strategy relies on reversible reactions between boronic acid surfactants and carbohydrates at the hydrocarbon/water interface leading to a dynamic reconfiguration of the droplet morphology, which alters the angular distribution of the droplet’s fluorescent light emission. We exploit this unique chemical–morphological–optical coupling to detect Salmonella enterica, a type of bacteria with a well-known binding affinity for mannose. We further demonstrate an oriented immobilization of antibodies at the droplet interface to permit higher selectivity. Our demonstrations yield a new, inexpensive, robust, and generalizable sensing strategy that can help to facilitate the early detection of foodborne pathogens.

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 Dates: 2019-05
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1021/acscentsci.9b00059
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Title: ACS Central Science
  Other : ACS Cent. Sci.
Source Genre: Journal
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Publ. Info: Washington : American Chemical Society
Pages: - Volume / Issue: 5 (5) Sequence Number: - Start / End Page: 789 - 795 Identifier: Other: 2374-7951