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  Transient perturbation of the left temporal cortex evokes plasticity‐related reconfiguration of the lexical network

Klaus, J., Schutter, D. J. L. G., & Piai, V. (2019). Transient perturbation of the left temporal cortex evokes plasticity‐related reconfiguration of the lexical network. Human Brain Mapping. doi:10.1002/hbm.24860.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-46F2-B Version Permalink: http://hdl.handle.net/21.11116/0000-0005-590C-B
Genre: Journal Article

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 Creators:
Klaus, Jana1, Author              
Schutter, Dennis J. L. G.2, 3, Author
Piai, Vitória2, 4, Author
Affiliations:
1Lise Meitner Research Group Cognition and Plasticity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3025665              
2Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands, ou_persistent22              
3Department of Experimental Psychology, Helmholtz Institute, Utrecht University, the Netherlands, ou_persistent22              
4Donders Centre for Medical Neuroscience, Radboud University, Nijmegen, the Netherlands, ou_persistent22              

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Free keywords: Cortical reorganization; cTBS; EEG; Language production
 Abstract: While much progress has been made in how brain organization supports language function, the language network's ability to adapt to immediate disturbances by means of reorganization remains unclear. The aim of this study was to examine acute reorganizational changes in brain activity related to conceptual and lexical retrieval in unimpaired language production following transient disruption of the left middle temporal gyrus (MTG). In a randomized single‐blind within‐subject experiment, we recorded the electroencephalogram from 16 healthy participants during a context‐driven picture‐naming task. Prior to the task, the left MTG was perturbed with real continuous theta‐burst stimulation (cTBS) or sham stimulation. During the task, participants read lead‐in sentences creating a constraining (e.g., “The farmer milks the”) or nonconstraining context (e.g., “The farmer buys the”). The last word was shown as a picture that participants had to name (e.g., “cow”). Replicating behavioral studies, participants were overall faster in naming pictures following a constraining relative to a nonconstraining context, but this effect did not differ between real and sham cTBS. In contrast, real cTBS increased overall error rates compared to sham cTBS. In line with previous studies, we observed a decrease in alpha‐beta (8–24 Hz) oscillatory power for constraining relative to nonconstraining contexts over left temporal–parietal cortex after participants received sham cTBS. However, following real cTBS, this decrease extended toward left prefrontal regions associated with both domain‐general and domain‐specific control mechanisms. Our findings provide evidence that immediately after perturbing the left MTG, the lexical‐semantic network is able to quickly reconfigure, also recruiting domain‐general regions.

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Language(s): eng - English
 Dates: 2019-09-302019-05-232019-10-282019-11-09
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/hbm.24860
Other: Epub ahead of print
PMID: 31705740
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Project name : -
Grant ID : KL 2933/2‐1
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Funding organization : German Research Foundation (DFG)
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Grant ID : 451‐17‐003
Funding program : -
Funding organization : Netherlands Organization for Scientific Research (NWO)

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Title: Human Brain Mapping
Source Genre: Journal
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Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 1065-9471
CoNE: https://pure.mpg.de/cone/journals/resource/954925601686