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  Reduction of fibrillar strain-rate sensitivity in steroid-induced osteoporosis linked to changes in mineralized fibrillar nanostructure

Xi, L., De Falco, P., Barbieri, E., Karunaratne, A., Bentley, L., Esapa, C., et al. (2020). Reduction of fibrillar strain-rate sensitivity in steroid-induced osteoporosis linked to changes in mineralized fibrillar nanostructure. Bone, 131: 115111. doi:10.1016/j.bone.2019.115111.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-4E77-F Version Permalink: http://hdl.handle.net/21.11116/0000-0005-6944-9
Genre: Journal Article

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Xi, L., Author
De Falco, Paolino1, Author              
Barbieri, E., Author
Karunaratne, A., Author
Bentley, L., Author
Esapa, C.T., Author
Davis, G.R., Author
Terrill, N.J., Author
Cox, R.D., Author
Pugno, N.M., Author
Thakker, R.V., Author
Weinkamer, Richard1, Author              
Wu, W.W., Author
Fang, D.N., Author
Gupta, H.S., Author
Affiliations:
1Richard Weinkamer, Biomaterialien, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863295              

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Free keywords: Glucocorticoid induced osteoporosis, Synchrotron X-ray nanomechanical imaging, Nanoscale deformation mechanisms, Multiscale Mechanical modelling
 Abstract: As bone is used in a dynamic mechanical environment, understanding the structural origins of its time-dependent mechanical behaviour – and the alterations in metabolic bone disease – is of interest. However, at the scale of the mineralized fibrillar matrix (nanometre-level), the nature of the strain-rate dependent mechanics is incompletely understood. Here, we investigate the fibrillar- and mineral-deformation behaviour in a murine model of Cushing’s syndrome, used to understand steroid induced osteoporosis, using synchrotron small- and wide-angle scattering/diffraction combined with in situ tensile testing at three strain rates ranging from 10-4 to 10-1 s-1. We find that the effective fibril- and mineral-modulus and fibrillar-reorientation show no significant increase with strain-rate in osteoporotic bone, but increase significantly in normal (wild-type) bone. By applying a fibril-lamellar two-level structural model of bone matrix deformation to fit the results, we obtain indications that altered collagen-mineral interactions at the nanoscale – along with altered fibrillar orientation distributions – may be the underlying reason for this altered strain-rate sensitivity. Our results suggest that an altered strain-rate sensitivity of the bone matrix in osteoporosis may be one of the contributing factors to reduced mechanical competence in such metabolic bone disorders, and that increasing this sensitivity may improve biomechanical performance.

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Language(s): eng - English
 Dates: 2019-11-112020
 Publication Status: Published in print
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 Identifiers: DOI: 10.1016/j.bone.2019.115111
BibTex Citekey: XI2020115111
Other: MS und PDF erbeten. AP03122019
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Title: Bone
Source Genre: Journal
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Pages: - Volume / Issue: 131 Sequence Number: 115111 Start / End Page: - Identifier: ISSN: 8756-3282