English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Nucleosome Remodeling by Fun30(SMARCAD1) in the DNA Damage Response

Bantele, S. C. S., & Pfander, B. (2019). Nucleosome Remodeling by Fun30(SMARCAD1) in the DNA Damage Response. FRONTIERS IN MOLECULAR BIOSCIENCES, 6: UNSP 78. doi:10.3389/fmolb.2019.00078.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0005-5281-C Version Permalink: http://hdl.handle.net/21.11116/0000-0005-5282-B
Genre: Journal Article
Other : Review

Files

show Files
hide Files
:
fmolb-06-00078.pdf (Any fulltext), 978KB
Name:
fmolb-06-00078.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
open access article
License:
-

Locators

show

Creators

show
hide
 Creators:
Bantele, Susanne C. S.1, Author              
Pfander, Boris1, Author              
Affiliations:
1Pfander, Boris / DNA Replication and Genome Integrity, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565165              

Content

show
hide
Free keywords: HISTONE H2A PHOSPHORYLATION; STRAND BREAK RESECTION; REPLICATION FACTOR-C; HOMOLOGOUS RECOMBINATION; END RESECTION; PROTEIN COMPLEXES; ANALYSIS REVEALS; STRUCTURAL BASIS; MISMATCH REPAIR; ATP UTILIZATIONBiochemistry & Molecular Biology; Fun30/SMARCAD1; nucleosome remodeling; DNA double-stranded break; DNA end resection; cell cycle; post-translational modification; genome stability;
 Abstract: Many cellular pathways are dedicated to maintain the integrity of the genome. In eukaryotes, the underlying DNA transactions occur in the context of chromatin. Cells utilize chromatin and its dynamic nature to regulate those genome integrity pathways. Accordingly, chromatin becomes restructured and modified around DNA damage sites. Here, we review the current knowledge of a chromatin remodeler Fun30(SMARCAD1) which plays a key role in genome maintenance. Fun30(SMARCAD1) promotes DNA end resection and the repair of DNA double-stranded breaks (DSBs). Notably, however, Fun30(SMARCAD1) plays additional roles in maintaining heterochromatin and promoting transcription. Overall, Fun30(SMARCAD1) is involved in distinct processes and the specific roles of Fun30(SMARCAD1) at DSBs, replication forks and sites of transcription appear discordant at first view. Nonetheless, a picture emerges in which commonalities within these context-dependent roles of Fun30(SMARCAD1) exist, which may help to gain a more global understanding of chromatin alterations induced by Fun30(SMARCAD1).

Details

show
hide
Language(s): eng - English
 Dates: 2019
 Publication Status: Published online
 Pages: 10
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: ISI: 000483844600001
DOI: 10.3389/fmolb.2019.00078
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: FRONTIERS IN MOLECULAR BIOSCIENCES
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND : FRONTIERS MEDIA SA
Pages: - Volume / Issue: 6 Sequence Number: UNSP 78 Start / End Page: - Identifier: -