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  Hyperpolarization of 15N-pyridinium and 15N-aniline derivatives by using parahydrogen: New opportunities to store nuclear spin polarization in aqueous media.

Jagtap, A., Kaltschnee, L., & Glöggler, S. (2019). Hyperpolarization of 15N-pyridinium and 15N-aniline derivatives by using parahydrogen: New opportunities to store nuclear spin polarization in aqueous media. Chemical Science, 10(37), 8577-8582. doi:10.1039/c9sc02970b.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-536E-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-5373-C
Genre: Journal Article

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Jagtap, A.1, Author              
Kaltschnee, L.1, Author              
Glöggler, S.1, Author              
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1Research Group of NMR Signal Enhancement, MPI for Biophysical Chemistry, Max Planck Society, ou_2396691              

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 Abstract: Hyperpolarization techniques hold the promise to improve the sensitivity of magnetic resonance imaging (MRI) contrast agents by over 10 000-fold. Among these techniques, para-hydrogen induced polarization (PHIP) allows for generating contrast agents within seconds. Typical hyperpolarized contrast agents are traceable for 2-3 minutes only, thus prolonging tracking-times holds great importance for the development of new ways to diagnose and monitor diseases. Here, we report on the design of perdeuterated 15N-containing molecules with longitudinal relaxation times (T 1) of several minutes. T 1 is a measure for how long hyperpolarization can be stored. In particular, we introduce two new hyperpolarizable families of compounds that we signal enhanced with para-hydrogen: tert-amine aniline derivatives and a quaternary pyridinium compound with 15N-T 1 of about 8 minutes. Especially the latter compound has great potential for applicability since we achieved 15N-polarization up to 8% and the pyridinium motif is contained in a variety of drug molecules and is also used in drug delivery systems.

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Language(s): eng - English
 Dates: 2019-08-062019
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1039/c9sc02970b
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Title: Chemical Science
Source Genre: Journal
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Pages: - Volume / Issue: 10 (37) Sequence Number: - Start / End Page: 8577 - 8582 Identifier: -