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  Impaired right temporoparietal junction-hippocampus connectivity in schizophrenia and its relevance for generating representations of other minds

Bitsch, F., Berger, P., Nagels, A., Falkenberg, I., & Straube, B. (2019). Impaired right temporoparietal junction-hippocampus connectivity in schizophrenia and its relevance for generating representations of other minds. SCHIZOPHRENIA BULLETIN, 45(4), 934-945. doi:10.1093/schbul/sby132.

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Genre: Journal Article

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 Creators:
Bitsch, Florian1, Author
Berger, Philipp1, Author              
Nagels, Arne2, Author
Falkenberg, Irina1, Author
Straube, Benjamin1, Author
Affiliations:
1Department of Psychiatry and Psychotherapy, Philipps-University Marburg, ou_persistent22              
2Department of English and Linguistics, Johannes Gutenberg-University Mainz, ou_persistent22              

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Free keywords: Theory of Mind; mentalizing; social cognition; social learning; social decision making; fMRI; psychotic disorder
 Abstract: Schizophrenia is associated with impaired and exaggerated Theory of Mind processes, pointing on alterations in generating a representation of another person's mind. Despite recent work on healthy subjects suggesting that a coupling between the right temporoparietal junction (rTPJ) and the hippocampus is relevant for building representations of others' intentions, the neural basis of related dysfunctions in patients with schizophrenia remains unclear. Therefore, we used structural and functional magnetic resonance imaging together with a modified prisoner's dilemma game to test the hypotheses, that patients show dysfunctional social updating on behavioral level accompanied by altered rTPJ-hippocampus coupling on a functional and a structural level. During the task, 31 patients with schizophrenia and 20 healthy controls interacted with 3 playing partners, who behaved according to stable strategies competitively, cooperatively, or randomly. Our data show that patients adapted their social behavior less flexibly to the playing partners than healthy controls, indicating differences in forming mental representations of the counterparts' intentions. Patients showed lower functional connectivity between the rTPJ and temporal lobe regions such as the hippocampus, the fusiform gyrus, and the middle temporal gyrus, indicating that in patients the rTPJ fails to integrate memory-informed processing streams during mental state inferences. Remarkably, the rTPJ-hippocampus coupling accounted for the participants' adaptive social behavior in the task, suggesting that a neural pathway relevant for updating social knowledge and forming forward predictions in social interactions is altered in schizophrenia.

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Language(s): eng - English
 Dates: 2018-09-182019-07
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: ISI: 000493375400026
DOI: 10.1093/schbul/sby132
PMID: 30239972
PMC: PMC6581138
 Degree: -

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Title: SCHIZOPHRENIA BULLETIN
  Other : Schizophr. Bull.
Source Genre: Journal
 Creator(s):
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Publ. Info: Rockville, MD : U.S. Dept. of Health, Education and Welfare, Public Health Service, Alcohol, Drug Abuse and Mental Health Administration
Pages: - Volume / Issue: 45 (4) Sequence Number: - Start / End Page: 934 - 945 Identifier: ISSN: 0586-7614
CoNE: https://pure.mpg.de/cone/journals/resource/954925532975