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  DeepCEST 3T: Robust MRI parameter determination and uncertainty quantification with neural networks-application to CEST imaging of the human brain at 3

Glang, F., Deshmane, A., Prokudin, S., Martin, F., Herz, K., Lindig, T., et al. (2020). DeepCEST 3T: Robust MRI parameter determination and uncertainty quantification with neural networks-application to CEST imaging of the human brain at 3. Magnetic Resonance in Medicine, 84(1), 450-466. doi:10.1002/mrm.28117.

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Glang, F1, 2, Autor           
Deshmane, A1, 2, Autor           
Prokudin, S, Autor
Martin, F1, 2, Autor           
Herz, K1, 2, Autor           
Lindig, T1, 2, Autor           
Bender, B, Autor           
Scheffler, K1, 2, Autor           
Zaiss, M1, 2, Autor           
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Zusammenfassung: Purpose: Calculation of sophisticated MR contrasts often requires complex mathematical modeling. Data evaluation is computationally expensive, vulnerable to artifacts, and often sensitive to fit algorithm parameters. In this work, we investigate whether neural networks can provide not only fast model fitting results, but also a quality metric for the predicted values, so called uncertainty quantification, investigated here in the context of multi‐pool Lorentzian fitting of CEST MRI spectra at 3T.
Methods

A deep feed‐forward neural network including a probabilistic output layer allowing for uncertainty quantification was set up to take uncorrected CEST‐spectra as input and predict 3T Lorentzian parameters of a 4‐pool model (water, semisolid MT, amide CEST, NOE CEST), including the B0 inhomogeneity. Networks were trained on data from 3 subjects with and without data augmentation, and applied to untrained data from 1 additional subject and 1 brain tumor patient. Comparison to conventional Lorentzian fitting was performed on different perturbations of input data.
Results

The deepCEST 3T networks provided fast and accurate predictions of all Lorentzian parameters and were robust to input perturbations because of noise or B0 artifacts. The uncertainty quantification detected fluctuations in input data by increase of the uncertainty intervals. The method generalized to unseen brain tumor patient CEST data.
Conclusions

The deepCEST 3T neural network provides fast and robust estimation of CEST parameters, enabling online reconstruction of sophisticated CEST contrast images without the typical computational cost. Moreover, the uncertainty quantification indicates if the predictions are trustworthy, enabling confident interpretation of contrast changes.

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 Datum: 2019-122020-07
 Publikationsstatus: Erschienen
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 Identifikatoren: DOI: 10.1002/mrm.28117
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Titel: Magnetic Resonance in Medicine
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: New York : Wiley-Liss
Seiten: - Band / Heft: 84 (1) Artikelnummer: - Start- / Endseite: 450 - 466 Identifikator: ISSN: 0740-3194
CoNE: https://pure.mpg.de/cone/journals/resource/954925538149