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  Neural representation of newly instructed rule identities during early implementation trials

Ruge, H., Schäfer, T. A. J., Zwosta, K., Mohr, H., & Wolfensteller, U. (2019). Neural representation of newly instructed rule identities during early implementation trials. eLife, 8: e48293. doi:10.7554/eLife.48293.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-5DAC-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-7ABF-C
Genre: Journal Article

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 Creators:
Ruge, Hannes1, Author
Schäfer, Theo A. J.1, 2, Author              
Zwosta, Katharina1, Author
Mohr, Holger1, Author
Wolfensteller, Uta1, Author
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1TU Dresden, Germany, ou_persistent22              
2Department Psychology (Doeller), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2591710              

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 Abstract: By following explicit instructions, humans instantaneously get the hang of tasks they have never performed before. We used a specially calibrated multivariate analysis technique to uncover the elusive representational states during the first few implementations of arbitrary rules such as ‘for coffee, press red button’ following their first-time instruction. Distributed activity patterns within the ventrolateral prefrontal cortex (VLPFC) indicated the presence of neural representations specific of individual stimulus-response (S-R) rule identities, preferentially for conditions requiring the memorization of instructed S-R rules for correct performance. Identity-specific representations were detectable starting from the first implementation trial and continued to be present across early implementation trials. The increasingly fluent application of novel rule representations was channelled through increasing cooperation between VLPFC and anterior striatum. These findings inform representational theories on how the prefrontal cortex supports behavioral flexibility specifically by enabling the ad-hoc coding of newly instructed individual rule identities during their first-time implementation.

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Language(s): eng - English
 Dates: 2019-05-082019-11-162019-11-29
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.7554/eLife.48293
PMID: 31738167
PMC: PMC6884394
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Project name : Volition und kognitive Kontrolle: Mechanismen, Modulatoren, Dysfunktionen / SFB 940
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Funding organization : Deutsche Forschungsgemeinschaft (DFG)

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Title: eLife
Source Genre: Journal
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Publ. Info: Cambridge : eLife Sciences Publications
Pages: - Volume / Issue: 8 Sequence Number: e48293 Start / End Page: - Identifier: ISSN: 2050-084X
CoNE: https://pure.mpg.de/cone/journals/resource/2050-084X