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  Traumatic and nontraumatic spinal cord injury: Pathological insights from neuroimaging

David, G., Mohammadi, S., Martin, A. R., Cohen-Adad, J., Weiskopf, N., Thompson, A., et al. (2019). Traumatic and nontraumatic spinal cord injury: Pathological insights from neuroimaging. Nature Reviews Neurology, 15, 718-731. doi:10.1038/s41582-019-0270-5.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-5DC7-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-7C44-4
Genre: Journal Article

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 Creators:
David, Gergely1, 2, Author
Mohammadi, Siawoosh2, 3, Author
Martin, Allan R.4, Author
Cohen-Adad, Julien5, Author
Weiskopf, Nikolaus3, 6, Author              
Thompson, Alan7, Author
Freund, Patrick1, 3, 6, 7, 8, Author              
Affiliations:
1Balgrist Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland, ou_persistent22              
2Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Germany, ou_persistent22              
3Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, United Kingdom, ou_persistent22              
4Department of Surgery, University of Toronto, ON, Canada, ou_persistent22              
5NeuroPoly Lab, Institute of Biomedical Engineering, École Polytechnique de Montréal, QC, Canada, ou_persistent22              
6Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
7Department of Brain Repair & Rehabilitation, University College London, United Kingdom, ou_persistent22              
8Department of Neurology, University Hospital Zurich, Switzerland, ou_persistent22              

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Free keywords: Magnetic resonance imaging; Neurodegeneration; Spinal cord diseases
 Abstract: Pathophysiological changes in the spinal cord white and grey matter resulting from injury can be observed with MRI techniques. These techniques provide sensitive markers of macrostructural and microstructural tissue integrity, which correlate with histological findings. Spinal cord MRI findings in traumatic spinal cord injury (tSCI) and nontraumatic spinal cord injury — the most common form of which is degenerative cervical myelopathy (DCM) — have provided important insights into the pathophysiological processes taking place not just at the focal injury site but also rostral and caudal to the spinal injury. Although tSCI and DCM have different aetiologies, they show similar degrees of spinal cord pathology remote from the injury site, suggesting the involvement of similar secondary degenerative mechanisms. Advanced quantitative MRI protocols that are sensitive to spinal cord pathology have the potential to improve diagnosis and, more importantly, predict outcomes in patients with tSCI or nontraumatic spinal cord injury. This Review describes the insights into tSCI and DCM that have been revealed by neuroimaging and outlines current activities and future directions for the field.

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Language(s): eng - English
 Dates: 2019-09-182019-10-312019-12
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41582-019-0270-5
Other: Epub 2019
PMID: 31673093
 Degree: -

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Project name : -
Grant ID : MO 2397/4-1
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft (DFG)
Project name : -
Grant ID : 01fmthh2017
Funding program : -
Funding organization : Forschungszentrum Medizintechnik Hamburg
Project name : -
Grant ID : 359116 ; 143263
Funding program : -
Funding organization : Canadian Institutes of Health Research (CIHR)
Project name : -
Grant ID : 950–230815
Funding program : -
Funding organization : Canada Research Chair in Quantitative Magnetic Resonance Imaging
Project name : -
Grant ID : 32454 ; 34824
Funding program : -
Funding organization : Canada Foundation for Innovation
Project name : -
Grant ID : 28826
Funding program : -
Funding organization : Fonds de Recherche du Québec – Santé
Project name : -
Grant ID : 435897-2013
Funding program : -
Funding organization : Natural Sciences and Engineering Research Council of Canada (NSERC)
Project name : -
Grant ID : -
Funding program : IVADO and TransMedTech
Funding organization : Canada First Research Excellence Fund (CFREF)
Project name : -
Grant ID : 5886
Funding program : -
Funding organization : Quebec Bio-Imaging Network (QBIN)
Project name : -
Grant ID : WFL-CH-007/14
Funding program : INSPIRED project
Funding organization : Wings for Life, Austria
Project name : Non-Invasive In-Vivo Histology in Health and Disease Using Magnetic Resonance Imaging (MRI) / HMRI
Grant ID : 616905
Funding program : Funding Programme 7
Funding organization : European Commission (EC)
Project name : Entschlüsselung der pathophysiologischen Prozesse induziert durch eine Querschnittlähmung: Anwendung von MRT basierter in vivo und ex vivo Histologie / hMRIofSCI
Grant ID : 01EW1711A ; 01EW1711B
Funding program : ERA-NET Neuron
Funding organization : German Federal Ministry of Education and Research (BMBF)
Project name : Taking imaging into the therapeutic domain: Self-regulation of brain systems for mental disorders / BRAINTRAIN
Grant ID : 602186
Funding program : Funding Programme 7
Funding organization : European Commission (EC)
Project name : Antibodies against Nogo-A to enhance plasticity, regeneration and functional recovery after acute spinal cord injury, a multicenter European clinical proof of concept trial / NISCI
Grant ID : 681094
Funding program : Horizon 2020
Funding organization : European Commission (EC)
Project name : -
Grant ID : 15.0137
Funding program : -
Funding organization : Swiss State Secretariat for Education, Research and Innovation (SERI)
Project name : -
Grant ID : -
Funding program : UCL Impact Awards
Funding organization : UCL
Project name : -
Grant ID : PCEFP3_181362/1
Funding program : SNF Eccellenza Professorial Fellowship Grant
Funding organization : Swiss National Science Foundation

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Title: Nature Reviews Neurology
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York, NY, USA : Nature Publ. Group
Pages: - Volume / Issue: 15 Sequence Number: - Start / End Page: 718 - 731 Identifier: ISSN: 1759-4758
CoNE: https://pure.mpg.de/cone/journals/resource/1759-4758