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  Traumatic and nontraumatic spinal cord injury: Pathological insights from neuroimaging

David, G., Mohammadi, S., Martin, A. R., Cohen-Adad, J., Weiskopf, N., Thompson, A., et al. (2019). Traumatic and nontraumatic spinal cord injury: Pathological insights from neuroimaging. Nature Reviews Neurology, 15, 718-731. doi:10.1038/s41582-019-0270-5.

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David, Gergely1, 2, Autor
Mohammadi, Siawoosh2, 3, Autor
Martin, Allan R.4, Autor
Cohen-Adad, Julien5, Autor
Weiskopf, Nikolaus3, 6, Autor           
Thompson, Alan7, Autor
Freund, Patrick1, 3, 6, 7, 8, Autor           
Affiliations:
1Balgrist Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland, ou_persistent22              
2Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Germany, ou_persistent22              
3Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, United Kingdom, ou_persistent22              
4Department of Surgery, University of Toronto, ON, Canada, ou_persistent22              
5NeuroPoly Lab, Institute of Biomedical Engineering, École Polytechnique de Montréal, QC, Canada, ou_persistent22              
6Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
7Department of Brain Repair & Rehabilitation, University College London, United Kingdom, ou_persistent22              
8Department of Neurology, University Hospital Zurich, Switzerland, ou_persistent22              

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Schlagwörter: Magnetic resonance imaging; Neurodegeneration; Spinal cord diseases
 Zusammenfassung: Pathophysiological changes in the spinal cord white and grey matter resulting from injury can be observed with MRI techniques. These techniques provide sensitive markers of macrostructural and microstructural tissue integrity, which correlate with histological findings. Spinal cord MRI findings in traumatic spinal cord injury (tSCI) and nontraumatic spinal cord injury — the most common form of which is degenerative cervical myelopathy (DCM) — have provided important insights into the pathophysiological processes taking place not just at the focal injury site but also rostral and caudal to the spinal injury. Although tSCI and DCM have different aetiologies, they show similar degrees of spinal cord pathology remote from the injury site, suggesting the involvement of similar secondary degenerative mechanisms. Advanced quantitative MRI protocols that are sensitive to spinal cord pathology have the potential to improve diagnosis and, more importantly, predict outcomes in patients with tSCI or nontraumatic spinal cord injury. This Review describes the insights into tSCI and DCM that have been revealed by neuroimaging and outlines current activities and future directions for the field.

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Sprache(n): eng - English
 Datum: 2019-09-182019-10-312019-12
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1038/s41582-019-0270-5
Anderer: Epub 2019
PMID: 31673093
 Art des Abschluß: -

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Projektname : -
Grant ID : MO 2397/4-1
Förderprogramm : -
Förderorganisation : Deutsche Forschungsgemeinschaft (DFG)
Projektname : -
Grant ID : 01fmthh2017
Förderprogramm : -
Förderorganisation : Forschungszentrum Medizintechnik Hamburg
Projektname : -
Grant ID : 359116 ; 143263
Förderprogramm : -
Förderorganisation : Canadian Institutes of Health Research (CIHR)
Projektname : -
Grant ID : 950–230815
Förderprogramm : -
Förderorganisation : Canada Research Chair in Quantitative Magnetic Resonance Imaging
Projektname : -
Grant ID : 32454 ; 34824
Förderprogramm : -
Förderorganisation : Canada Foundation for Innovation
Projektname : -
Grant ID : 28826
Förderprogramm : -
Förderorganisation : Fonds de Recherche du Québec – Santé
Projektname : -
Grant ID : 435897-2013
Förderprogramm : -
Förderorganisation : Natural Sciences and Engineering Research Council of Canada (NSERC)
Projektname : -
Grant ID : -
Förderprogramm : IVADO and TransMedTech
Förderorganisation : Canada First Research Excellence Fund (CFREF)
Projektname : -
Grant ID : 5886
Förderprogramm : -
Förderorganisation : Quebec Bio-Imaging Network (QBIN)
Projektname : -
Grant ID : WFL-CH-007/14
Förderprogramm : INSPIRED project
Förderorganisation : Wings for Life, Austria
Projektname : Non-Invasive In-Vivo Histology in Health and Disease Using Magnetic Resonance Imaging (MRI) / HMRI
Grant ID : 616905
Förderprogramm : Funding Programme 7
Förderorganisation : European Commission (EC)
Projektname : Entschlüsselung der pathophysiologischen Prozesse induziert durch eine Querschnittlähmung: Anwendung von MRT basierter in vivo und ex vivo Histologie / hMRIofSCI
Grant ID : 01EW1711A ; 01EW1711B
Förderprogramm : ERA-NET Neuron
Förderorganisation : German Federal Ministry of Education and Research (BMBF)
Projektname : Taking imaging into the therapeutic domain: Self-regulation of brain systems for mental disorders / BRAINTRAIN
Grant ID : 602186
Förderprogramm : Funding Programme 7
Förderorganisation : European Commission (EC)
Projektname : Antibodies against Nogo-A to enhance plasticity, regeneration and functional recovery after acute spinal cord injury, a multicenter European clinical proof of concept trial / NISCI
Grant ID : 681094
Förderprogramm : Horizon 2020
Förderorganisation : European Commission (EC)
Projektname : -
Grant ID : 15.0137
Förderprogramm : -
Förderorganisation : Swiss State Secretariat for Education, Research and Innovation (SERI)
Projektname : -
Grant ID : -
Förderprogramm : UCL Impact Awards
Förderorganisation : UCL
Projektname : -
Grant ID : PCEFP3_181362/1
Förderprogramm : SNF Eccellenza Professorial Fellowship Grant
Förderorganisation : Swiss National Science Foundation

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Titel: Nature Reviews Neurology
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: New York, NY, USA : Nature Publ. Group
Seiten: - Band / Heft: 15 Artikelnummer: - Start- / Endseite: 718 - 731 Identifikator: ISSN: 1759-4758
CoNE: https://pure.mpg.de/cone/journals/resource/1759-4758