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  In vivo Firre and Dxz4 deletion elucidates roles for autosomal gene regulation

Andergassen, D., Smith, Z. D., Lewandowski, J. P., Gerhardinger, C., Meissner, A., & Rinn, J. L. (2019). In vivo Firre and Dxz4 deletion elucidates roles for autosomal gene regulation. eLife, 8: e47214. doi:10.7554/eLife.47214.001.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-6216-4 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-6217-3
Genre: Journal Article

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Andergassen, Daniel , Author
Smith, Zachary D. , Author
Lewandowski, Jordan P. , Author
Gerhardinger, Chiara , Author
Meissner, Alexander1, Author              
Rinn, John L., Author
Affiliations:
1Dept. of Genome Regulation (Head: Alexander Meissner), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_2379694              

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 Abstract: Recent evidence has determined that the conserved X chromosome mega-structurescontrolled by theFirreandDxz4loci are not required for X chromosome inactivation (XCI) in celllines. Here, we examined the in vivo contribution of these loci by generating mice carrying a singleor double deletion ofFirreandDxz4. We found that these mutants are viable, fertile and show nodefect in random or imprinted XCI. However, the lack of these elements results in manydysregulated genes on autosomes in an organ-specific manner. By comparing the dysregulatedgenes between the single and double deletion, we identified superloop, megadomain, andFirrelocus-dependent gene sets. The largest transcriptional effect was observed in all strains lacking theFirrelocus, indicating that this locus is the main driver for these autosomal expression signatures.Collectively, these findings suggest that these X-linked loci are involved in autosomal generegulation rather than XCI biology.

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Language(s): eng - English
 Dates: 2019-10-302019-11-18
 Publication Status: Published online
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 Rev. Type: -
 Identifiers: DOI: 10.7554/eLife.47214.001
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Title: eLife
Source Genre: Journal
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Publ. Info: Cambridge : eLife Sciences Publications
Pages: - Volume / Issue: 8 Sequence Number: e47214 Start / End Page: - Identifier: ISSN: 2050-084X
CoNE: https://pure.mpg.de/cone/journals/resource/2050-084X