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  Reshaping cortical activity with subthalamic stimulation in Parkinson's disease during finger tapping and gait mapped by near infrared spectroscopy

Klempir, O., Krupicka, R., Mehnert, J., Cejka, V., Polakova, K., Brozova, H., et al. (2019). Reshaping cortical activity with subthalamic stimulation in Parkinson's disease during finger tapping and gait mapped by near infrared spectroscopy. Journal of Applied Biomedicine, 17, 157-166. doi:10.32725/jab.2019.014.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-625E-4 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-625F-3
Genre: Journal Article

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 Creators:
Klempir, Ondrej1, Author
Krupicka, Radim1, Author
Mehnert, Jan2, 3, Author              
Cejka, Vaclav1, 4, Author
Polakova, Kamila4, Author
Brozova, Hana4, Author
Szabo, Zoltan1, Author
Ruzicka, Evzen4, Author
Jech, Robert4, Author
Affiliations:
1Faculty of Biomedical Engineering, Czech Technical University, Prague, Czech Republic, ou_persistent22              
2Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Germany, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
4Department of Neurology, First Faculty of Medicine, Charles University, Prague, Czech Republic, ou_persistent22              

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Free keywords: Deep brain stimulation; Gait; Near infrared spectroscopy; Neuroinformatics; Parkinson's disease; Subthalamic nucleus
 Abstract: Exploration of motor cortex activity is essential to understanding the pathophysiology in Parkinson's Disease (PD), but only simple motor tasks can be investigated using a fMRI or PET. We aim to investigate the cortical activity of PD patients during a complex motor task (gait) to verify the impact of deep brain stimulation in the subthalamic nucleus (DBS-STN) by using Near-Infrared-Spectroscopy (NIRS). NIRS is a neuroimaging method of brain cortical activity using low-energy optical radiation to detect local changes in (de)oxyhemoglobin concentration. We used a multichannel portable NIRS during finger tapping (FT) and gait. To determine the signal activity, our methodology consisted of a pre-processing phase for the raw signal, followed by statistical analysis based on a general linear model. Processed recordings from 9 patients were statistically compared between the on and off states of DBS-STN. DBS-STN led to an increased activity in the contralateral motor cortex areas during FT. During gait, we observed a concentration of activity towards the cortex central area in the "stimulation-on" state. Our study shows how NIRS can be used to detect functional changes in the cortex of patients with PD with DBS-STN and indicates its future use for applications unsuited for PET and a fMRI.

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Language(s): eng - English
 Dates: 2018-05-302019-08-192019-09-112019-09-18
 Publication Status: Published in print
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 Identifiers: DOI: 10.32725/jab.2019.014
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Title: Journal of Applied Biomedicine
Source Genre: Journal
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Publ. Info: České Budějovice : University of South Bohemia
Pages: - Volume / Issue: 17 Sequence Number: - Start / End Page: 157 - 166 Identifier: ISSN: 1214-021X
CoNE: https://pure.mpg.de/cone/journals/resource/1214-021X