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  Addiction Research Consortium: Losing and regaining control over drug intake (ReCoDe)-From trajectories to mechanisms and interventions

Heinz, A., Kiefer, F., Smolka, M., Endrass, T., Beste, C., Beck, A., et al. (2020). Addiction Research Consortium: Losing and regaining control over drug intake (ReCoDe)-From trajectories to mechanisms and interventions. Addiction Biology, 25(2), 1-6. doi:10.1111/adb.12866.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-6791-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-9F7A-0
Genre: Journal Article

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 Creators:
Heinz, A, Author
Kiefer, F, Author
Smolka, MN, Author
Endrass, T, Author
Beste, C, Author
Beck, A, Author
Liu, S, Author
Genauck , A, Author
Romund, L, Author
Banaschewski, T, Author
Bermpohl, F, Author
Derserno, L, Author
Dolan, RJ, Author
Durstewitz, D, Author
Ebner-Priemer, U, Author
Flor, H, Author
Hansson, AC, Author
Heim, C, Author
Hermann, D, Author
Kiebel, S, Author
Kirsch, P, AuthorKirschbaum, C, AuthorKoppe, G, AuthorMarxen, M, AuthorMeyer-Lindenberg , A, AuthorNagel, WE, AuthorNoori, HR1, 2, Author              Pilhatsch, M, AuthorPriller, J, AuthorRietschel, M, AuthorRomanczuk-Seiferth, N, AuthorSchlagenhauf, F, AuthorSommer, WH, AuthorStallkamp, J, AuthorStröhle, A, AuthorStock, AC, AuthorWinterer, G, AuthorWinter, C, AuthorWalter, H, AuthorWitt, S, AuthorVollstädt-Klein, S, AuthorRapp, MA, AuthorTost, H, AuthorSpanagel, R, Author more..
Affiliations:
1Research Group Neuronal Convergence, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528694              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: One of the major risk factors for global death and disability is alcohol, tobacco, and illicit drug use. While there is increasing knowledge with respect to individual factors promoting the initiation and maintenance of substance use disorders (SUDs), disease trajectories involved in losing and regaining control over drug intake (ReCoDe) are still not well described. Our newly formed German Collaborative Research Centre (CRC) on ReCoDe has an interdisciplinary approach funded by the German Research Foundation (DFG) with a 12-year perspective. The main goals of our research consortium are (i) to identify triggers and modifying factors that longitudinally modulate the trajectories of losing and regaining control over drug consumption in real life, (ii) to study underlying behavioral, cognitive, and neurobiological mechanisms, and (iii) to implicate mechanism-based interventions. These goals will be achieved by: (i) using mobile health (m-health) tools to longitudinally monitor the effects of triggers (drug cues, stressors, and priming doses) and modify factors (eg, age, gender, physical activity, and cognitive control) on drug consumption patterns in real-life conditions and in animal models of addiction; (ii) the identification and computational modeling of key mechanisms mediating the effects of such triggers and modifying factors on goal-directed, habitual, and compulsive aspects of behavior from human studies and animal models; and (iii) developing and testing interventions that specifically target the underlying mechanisms for regaining control over drug intake.

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 Dates: 2019-122020-03
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1111/adb.12866
eDoc: e12866
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Title: Addiction Biology
  Other : Addict. Biol.
Source Genre: Journal
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Publ. Info: Abingdon, Oxfordshire, UK : Carfax
Pages: - Volume / Issue: 25 (2) Sequence Number: - Start / End Page: 1 - 6 Identifier: ISSN: 1355-6215
CoNE: https://pure.mpg.de/cone/journals/resource/954925277561