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  Effects of a male meiotic driver on male and female transcriptomes in the house mouse

Lindholm, A., Sutter, A., Künzel, S., Tautz, D., & Rehrauer, H. (2019). Effects of a male meiotic driver on male and female transcriptomes in the house mouse. Proceedings of the Royal Society B: Biological Sciences, 286(1915): 20191927. doi:10.1098/rspb.2019.1927.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-6892-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-6893-0
Genre: Journal Article

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 Creators:
Lindholm, Anna, Author
Sutter, Andreas, Author
Künzel, Sven1, Author              
Tautz, Diethard1, Author              
Rehrauer, Hubert, Author
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1Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445635              

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 Abstract: Not all genetic loci follow Mendel's rules, and the evolutionary consequences of this are not yet fully known. Genomic conflict involving multiple loci is a likely outcome, as restoration of Mendelian inheritance patterns will be selected for, and sexual conflict may also arise when sexes are differentially affected. Here, we investigate effects of the t haplotype, an autosomal male meiotic driver in house mice, on genome-wide gene expression patterns in males and females. We analysed gonads, liver and brain in adult same-sex sibling pairs differing in genotype, allowing us to identify t-associated differences in gene regulation. In testes, only 40% of differentially expressed genes mapped to the approximately 708 annotated genes comprising the t haplotype. Thus, much of the activity of the t haplotype occurs in trans, and as upregulation. Sperm maturation functions were enriched among both cis and trans acting t haplotype genes. Within the t haplotype, we observed more downregulation and differential exon usage. In ovaries, liver and brain, the majority of expression differences mapped to the t haplotype, and were largely independent of the differences seen in the testis. Overall, we found widespread transcriptional effects of this male meiotic driver in the house mouse genome.

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Language(s): eng - English
 Dates: 2019-08-222019-10-212019-11-132019-11
 Publication Status: Published in print
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 Identifiers: DOI: 10.1098/rspb.2019.1927
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Title: Proceedings of the Royal Society B: Biological Sciences
  Abbreviation : Proc. R. Soc. B
Source Genre: Journal
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Publ. Info: London : Royal Society
Pages: 20191927 Volume / Issue: 286 (1915) Sequence Number: 20191927 Start / End Page: - Identifier: ISSN: 0962-8452
CoNE: https://pure.mpg.de/cone/journals/resource/110975500577295_2