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  Molecular glue concept solidifies

Baek, K., & Schulman, B. (2020). Molecular glue concept solidifies. NATURE CHEMICAL BIOLOGY, 16(1), 2-3. doi:10.1038/s41589-019-0414-3.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-73B8-A Version Permalink: http://hdl.handle.net/21.11116/0000-0005-73B9-9
Genre: Journal Article

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 Creators:
Baek, Kheewong1, Author              
Schulman, Brenda1, Author              
Affiliations:
1Schulman, Brenda / Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Max Planck Society, ou_2466699              

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Free keywords: SELECTIVE DEGRADATION; STRUCTURAL BASIS
 Abstract: Molecular-glue-mediated proximity-induced degradation now allows unprecedented therapeutic targeting of previously undruggable proteins. Structures showing how aryl-sulfonamides mediate recruitment of the splicing factor RBM39 to the E3 CRL4(DCAF15) broaden the mechanistic principles by which molecular glues target ubiquitylation.

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Language(s): eng - English
 Dates: 2020
 Publication Status: Published in print
 Pages: 2
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: ISI: 000503057200005
DOI: 10.1038/s41589-019-0414-3
 Degree: -

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Title: NATURE CHEMICAL BIOLOGY
Source Genre: Journal
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Affiliations:
Publ. Info: 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA : NATURE PUBLISHING GROUP
Pages: - Volume / Issue: 16 (1) Sequence Number: - Start / End Page: 2 - 3 Identifier: ISSN: 1552-4450