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  Bottom-up synthetic biology: reconstitution in space and time

Jia, H., & Schwille, P. (2019). Bottom-up synthetic biology: reconstitution in space and time. Current Opinion in Biotechnology, 60, 179-187. doi:10.1016/j.copbio.2019.05.008.

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Genre: Journal Article

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 Creators:
Jia, Haiyang1, Author              
Schwille, Petra1, Author              
Affiliations:
1Schwille, Petra / Cellular and Molecular Biophysics, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565169              

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Free keywords: ACTIN-FILAMENTS; GENE-EXPRESSION; CELL; MYOSIN; LIPOSOMES; RINGS; OSCILLATIONS; ARCHITECTURE; REGULATORS; MEMBRANES
 Abstract: Bottom-up reconstituting well-characterized functional molecular entities, parts and modules towards a synthetic cell will give new insights into the mechanisms and origin of life. However, a remaining central challenge is how to organize cellular processes spatiotemporally from their component parts in vitro. Here, we review cutting edge tools and technologies that can facilitate such a bottom-up reconstitution towards a synthetic cell in space and time, particularly with regard to the following aspects: (1) reliable model membrane-environment and microenvironment; (2) dynamic genetic regulation and self-sustaining transcription and translation machinery; (3) spatially organized cytoskeleton that supports the biological architecture and cellular self-reproduction in 3D.

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Language(s): eng - English
 Dates: 2019-12
 Publication Status: Published in print
 Pages: 9
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: Current Opinion in Biotechnology
  Other : Curr. Opin. Biotechnol.
Source Genre: Journal
 Creator(s):
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Publ. Info: London : Elsevier Current Trends
Pages: - Volume / Issue: 60 Sequence Number: - Start / End Page: 179 - 187 Identifier: ISSN: 0958-1669
CoNE: https://pure.mpg.de/cone/journals/resource/954925577053