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  Proteasomes: unfoldase-assisted protein degradation machines

Majumder, P., & Baumeister, W. (2020). Proteasomes: unfoldase-assisted protein degradation machines. Biological Chemistry; W. de Gruyter, Berlin, 401(1), 183-199. doi:10.1515/hsz-2019-0344.

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Genre: Journal Article
Alternative Title : Review

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 Creators:
Majumder, Parijat1, Author              
Baumeister, Wolfgang1, Author              
Affiliations:
1Baumeister, Wolfgang / Molecular Structural Biology, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565142              

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Free keywords: 26S PROTEASOME; 20S PROTEASOME; DEUBIQUITINATING ENZYME; STRUCTURAL INSIGHTS; REGULATORY PARTICLE; CRYO-EM; THERMOPLASMA-ACIDOPHILUM; AUTOPHAGIC DEGRADATION; BACTERIAL PROTEASOME; REVEALS MECHANISMS19S RP; 20S proteasome; MPA; PAN; proteasome activators; VAT;
 Abstract: Proteasomes are the principal molecular machines for the regulated degradation of intracellular proteins. These self- compartmentalized macromolecular assemblies selectively degrade misfolded, mistranslated, damaged or otherwise unwanted proteins, and play a pivotal role in the maintenance of cellular proteostasis, in stress response, and numerous other processes of vital importance. Whereas the molecular architecture of the proteasome core particle (CP) is universally conserved, the unfoldase modules vary in overall structure, subunit complexity, and regulatory principles. Proteasomal unfoldases are AAA+ ATPases (ATPases associated with a variety of cellular activities) that unfold protein substrates, and -translocate them into the CP for degradation. In this review, we summarize the current state of knowledge about proteasome - unfoldase systems in bacteria, archaea, and eukaryotes, the three domains of life.

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Language(s): eng - English
 Dates: 20192020
 Publication Status: Published in print
 Pages: 17
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: ISI: 000501342700012
DOI: 10.1515/hsz-2019-0344
 Degree: -

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Title: Biological Chemistry; W. de Gruyter, Berlin
Source Genre: Journal
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Publ. Info: GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY : WALTER DE GRUYTER GMBH
Pages: - Volume / Issue: 401 (1) Sequence Number: - Start / End Page: 183 - 199 Identifier: ISSN: 1431-6730