Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
  Functional identity of hypothalamic melanocortin neurons depends on Tbx3

Quarta, C., Fisette, A., Xu, Y., Collden, G., Legutko, B., Tseng, Y.-T., et al. (2019). Functional identity of hypothalamic melanocortin neurons depends on Tbx3. NATURE METABOLISM, 1(2), 222-235. doi:10.1038/s42255-018-0028-1.

Item is

Basisdaten

einblenden: ausblenden:
Genre: Zeitschriftenartikel

Externe Referenzen

einblenden:

Urheber

einblenden:
ausblenden:
 Urheber:
Quarta, Carmelo1, Autor
Fisette, Alexandre1, Autor
Xu, Yanjun1, Autor
Collden, Gustav1, Autor
Legutko, Beata1, Autor
Tseng, Yu-Ting1, Autor
Reim, Alexander2, Autor           
Wierer, Michael2, Autor           
De Rosa, Maria Caterina1, Autor
Klaus, Valentina1, Autor
Rausch, Rick1, Autor
Thaker, Vidhu V.1, Autor
Graf, Elisabeth1, Autor
Strom, Tim M.1, Autor
Poher, Anne-Laure1, Autor
Gruber, Tim1, Autor
Le Thuc, Ophelia1, Autor
Cebrian-Serrano, Alberto1, Autor
Kabra, Dhiraj1, Autor
Bellocchio, Luigi1, Autor
Woods, Stephen C.1, AutorPflugfelder, Gert O.1, AutorNogueiras, Ruben1, AutorZeltser, Lori1, AutorKadow, Ilona C. Grunwald1, AutorMoon, Anne1, AutorGarcia-Caceres, Cristina1, AutorMann, Matthias2, Autor           Treier, Mathias1, AutorDoege, Claudia A.1, AutorTschoep, Matthias H.1, Autor mehr..
Affiliations:
1external, ou_persistent22              
2Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565159              

Inhalt

einblenden:
ausblenden:
Schlagwörter: ULNAR-MAMMARY SYNDROME; POMC NEURONS; FOOD-INTAKE; ARCUATE NUCLEUS; HUMAN INTERACTOME; GENE-EXPRESSION; AGRP NEURONS; BRAIN-STEM; DIFFERENTIATION; LEPTIN
 Zusammenfassung: Heterogeneous populations of hypothalamic neurons orchestrate energy balance via the release of specific signatures of neuro-peptides. However, how specific intracellular machinery controls peptidergic identities and function of individual hypothalamic neurons remains largely unknown. The transcription factor T-box 3 (Tbx3) is expressed in hypothalamic neurons sensing and governing energy status, whereas human TBX3 haploinsufficiency has been linked with obesity. Here, we demonstrate that loss of Tbx3 function in hypothalamic neurons causes weight gain and other metabolic disturbances by disrupting both the peptidergic identity and plasticity of Pomc/Cart and Agrp/Npy neurons. These alterations are observed after loss of Tbx3 in both immature hypothalamic neurons and terminally differentiated mouse neurons. We further establish the importance of Tbx3 for body weight regulation in Drosophila melanogaster and show that TBX3 is implicated in the differentiation of human embryonic stem cells into hypothalamic Pomc neurons. Our data indicate that Tbx3 directs the terminal specification of neurons as functional components of the melanocortin system and is required for maintaining their peptidergic identity. In summary, we report the discovery of a key mechanistic process underlying the functional heterogeneity of hypothalamic neurons governing body weight and systemic metabolism.

Details

einblenden:
ausblenden:
Sprache(n): eng - English
 Datum: 2019
 Publikationsstatus: Erschienen
 Seiten: 14
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: ISI: 000500728400007
DOI: 10.1038/s42255-018-0028-1
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: NATURE METABOLISM
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND : NATURE PUBLISHING GROUP
Seiten: - Band / Heft: 1 (2) Artikelnummer: - Start- / Endseite: 222 - 235 Identifikator: -