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  Prediction and mismatch negativity responses reflect impairments in action semantic processing in adults with autism spectrum disorders

Grisoni, L., Moseley, R. L., Motlagh, S., Kandia, D., Sener, N., Pulvermüller, F., et al. (2019). Prediction and mismatch negativity responses reflect impairments in action semantic processing in adults with autism spectrum disorders. Frontiers in Human Neuroscience, 13: 395. doi:10.3389/fnhum.2019.00395.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0005-6E0B-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-FFC7-B
Genre: Journal Article

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 Creators:
Grisoni, Luigi1, Author
Moseley, Rachel L.2, Author
Motlagh, Shiva3, Author
Kandia, Dimitra1, 4, Author              
Sener, Neslihan1, Author
Pulvermüller, Friedemann1, 3, 5, Author
Roepke, Stefan6, Author
Mohr, Bettina6, 7, Author
Affiliations:
1Brain Language Laboratory, Department of Philosophy and Humanities, FU Berlin, Germany, ou_persistent22              
2Department of Psychology, University of Bournemouth, Poole, United Kingdom, ou_persistent22              
3Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              
4Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
5Einstein Center for Neurosciences Berlin (ECN), Germany, ou_persistent22              
6Department Psychiatry, Charité University Medicine Berlin, Germany, ou_persistent22              
7Zentrum für Neuropsychologie und Intensive Sprachtherapie (ZeNIS), Berlin, Germany, ou_persistent22              

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Free keywords: Autism spectrum disorders; Prediction potential; Mismatch negativity; Grounded cognition; Event-related potentials
 Abstract: The neurophysiological mechanisms underlying motor and language difficulties in autism spectrum disorders (ASD) are still largely unclear. The present work investigates biological indicators of sound processing, (action-) semantic understanding and predictive coding and their correlation with clinical symptoms of ASD. Twenty-two adults with high-functioning ASD and 25 typically developed (TD) participants engaged in an auditory, passive listening, Mismatch Negativity (MMN) task while high-density electroencephalography (EEG) was recorded. Action and non-action words were presented in the context of sounds, which were either semantically congruent with regard to the body part they relate to or semantically incongruent or unrelated. The anticipatory activity before sound onset, the Prediction Potential (PP), was significantly reduced in the ASD group specifically for action, but not for non-action sounds. The early-MMN-like responses to words (latency: 120 ms) were differentially modulated across groups: controls showed larger amplitudes for words in action-sound compared to non-action contexts, whereas ASD participants demonstrated enlarged early-MMN-like responses only in a pure tone context, with no other modulation dependent on action sound context. Late-MMN-like responses around 560 ms post-stimulus onset revealed body-part-congruent action-semantic priming for words in control participants, but not in the ASD group. Importantly, neurophysiological indices of semantic priming in ASD participants correlated with the extent of autistic traits as revealed by the Autism Spectrum Quotient (AQ). The data suggest that high-functioning adults with ASD show a specific deficit in semantic processing and predictive coding of sounds and words related to action, which is absent for neutral, non-action, sounds.

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Language(s): eng - English
 Dates: 2019-05-152019-10-222019-11-14
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.3389/fnhum.2019.00395
Other: eCollection 2019
PMID: 31798432
PMC: PMC6868096
 Degree: -

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Project name : The sound of meaning
Grant ID : PU 97/22-1
Funding program : -
Funding organization : German Research Foundation (DFG)
Project name : Phonological networks in Language Production and Comprehension / PhoNet
Grant ID : PU 97/25-1
Funding program : -
Funding organization : French Agence Nationale de la Recherche (ANR) and the Deutsche Forschungsgemeinschaft (DFG)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Charite - University Medicine Berlin

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Title: Frontiers in Human Neuroscience
  Abbreviation : Front Hum Neurosci
Source Genre: Journal
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Affiliations:
Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 13 Sequence Number: 395 Start / End Page: - Identifier: ISSN: 1662-5161
CoNE: https://pure.mpg.de/cone/journals/resource/1662-5161